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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Durability of ChAdOx1 nCoV-19 vaccination in people living with HIV
JCI Insight, Volume 7, No. 7, Article e157031, Year 2022
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Description
Duration of protection from SARS-CoV-2 infection in people living with HIV (PWH) following vaccination is unclear. In a substudy of the phase II/III the COV002 trial (NCT04400838), 54 HIV+ male participants on antiretroviral therapy (undetectable viral loads, CD4+ T cells > 350 cells/μL) received 2 doses of ChAdOx1 nCoV-19 (AZD1222) 4-6 weeks apart and were followed for 6 months. Responses to vaccination were determined by serology (IgG ELISA and Meso Scale Discovery [MSD]), neutralization, ACE-2 inhibition, IFN-γ ELISpot, activation-induced marker (AIM) assay and T cell proliferation. We show that, 6 months after vaccination, the majority of measurable immune responses were greater than prevaccination baseline but with evidence of a decline in both humoral and cell-mediated immunity. There was, however, no significant difference compared with a cohort of HIV-uninfected individuals vaccinated with the same regimen. Responses to the variants of concern were detectable, although they were lower than WT. Preexisting cross-reactive T cell responses to SARS-CoV-2 spike were associated with greater postvaccine immunity and correlated with prior exposure to beta coronaviruses. These data support the ongoing policy to vaccinate PWH against SARS-CoV-2, and they underpin the need for long-term monitoring of responses after vaccination. © 2022, Ogbe et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC9057612/bin/jciinsight-7-157031-s216.pdf
Authors & Co-Authors
Ogbe, Ane T.
United Kingdom, Oxford
University of Oxford
Pace, Matthew J.
United Kingdom, Oxford
University of Oxford
Bittaye, Mustapha
United Kingdom, Oxford
The Jenner Institute
Tipoe, Timothy
United Kingdom, Oxford
University of Oxford
Adele, Sandra
United Kingdom, Oxford
University of Oxford
Alagaratnam, Jasmini
United Kingdom, London
Imperial College London
United Kingdom, London
Imperial College Healthcare Nhs Trust
Aley, Parvinder K.
United Kingdom, Oxford
University of Oxford
Ansari, M. Azim
United Kingdom, Oxford
University of Oxford
Brown, Anthony
United Kingdom, Oxford
University of Oxford
Brown, Helen L.
United Kingdom, Oxford
University of Oxford
Cappuccini, Federica
United Kingdom, Oxford
The Jenner Institute
Dejnirattisai, Wanwisa
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Ewer, Katie J.
United Kingdom, Oxford
The Jenner Institute
Folegatti, Pedro Moreira
United Kingdom, Oxford
The Jenner Institute
Goodman, Anna L.
United Kingdom, London
Guy's and st Thomas' Nhs Foundation Trust
Jenkin, Daniel
United Kingdom, Oxford
The Jenner Institute
Jones, Matthew G.
United Kingdom, Oxford
University of Oxford
Longet, Stéphanie
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Marchevsky, Natalie G.
United Kingdom, Oxford
University of Oxford
Mujadidi, Yama F.
United Kingdom, Oxford
University of Oxford
Parolini, Lucia
United Kingdom, Oxford
University of Oxford
Plested, Emma L.
United Kingdom, Oxford
University of Oxford
Pollock, Katrina M.
United Kingdom, London
Imperial College London
Ramasamy, Maheshi N.
United Kingdom, Oxford
University of Oxford
Rhead, Sarah
United Kingdom, Oxford
University of Oxford
Robinson, Hannah C.
United Kingdom, Oxford
University of Oxford
Robinson, Nicola
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Tipton, Tom R.W.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Zacharopoulou, Panagiota
United Kingdom, Oxford
University of Oxford
Barnes, Eleanor J.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
The Jenner Institute
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Dunachie, Susanna J.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Thailand, Bangkok
Mahidol Oxford Tropical Medicine Research Unit
Goulder, Philip Jeremy Renshaw
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Klenerman, Paul
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Screaton, Gavin Robert
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Winston, Alan
United Kingdom, London
Imperial College London
United Kingdom, London
Imperial College Healthcare Nhs Trust
Hill, Adrian V. S.
United Kingdom, Oxford
The Jenner Institute
Gilbert, Sarah C.
United Kingdom, Oxford
The Jenner Institute
Carroll, Miles W.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, London
Public Health England
Pollard, Andrew J.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Fidler, Sarah J.
United Kingdom, London
Imperial College London
United Kingdom, London
Imperial College Healthcare Nhs Trust
Fox, Julie Meriel
United Kingdom, London
Nihr Guy's and st Thomas' Biomedical Research Centre
United Kingdom, London
Guy's and st Thomas' Nhs Foundation Trust
Lambe, Teresa
United Kingdom, Oxford
The Jenner Institute
Frater, John
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Statistics
Citations: 26
Authors: 43
Affiliations: 11
Identifiers
Doi:
10.1172/jci.insight.157031
ISSN:
23793708
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cohort Study
Participants Gender
Male