Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Assessment of three new parasite lactate dehydrogenase (pan-pLDH) tests for diagnosis of uncomplicated malaria
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 102, No. 1, Year 2008
Notification
URL copied to clipboard!
Description
A study to assess the diagnostic capabilities of three parasite lactate dehydrogenase (pan-pLDH) tests, Vistapan®, Carestart™ and Parabank®, was conducted in Uganda. An HRP2 test, Paracheck-Pf®, and a Giemsa-stained blood film were performed with the pLDH tests for outpatients with suspected malaria. In total, 460 subjects were recruited: 248 with positive blood films and 212 with negative blood films. Plasmodium falciparum was present in 95% of infections. Sensitivity above 90% was shown by two pLDH tests, Carestart (95.6%) and Vistapan (91.9%), and specificity above 90% by Parabank (94.3%) and Carestart (91.5%). Sensitivity decreased with low parasitaemia (χ2 trend, P < 0.001); however, all tests achieved sensitivity >90% with parasitaemia ≥100/μl. All tests had good inter-reader reliability (κ > 0.95). Two weeks after diagnosis, 4-10% of pLDH tests were still positive compared with 69.7% of the HRP2 tests. All tests had similar ease of use. In conclusion, two pLDH tests performed well in diagnosing P. falciparum malaria, and all pLDH tests became negative after treatment more quickly than the HRP2. Therefore the rapid test of choice for use with artemisinin-combination therapies in this area would be one of these new pLDH tests. © 2007 Royal Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Fogg, Carole
France, Paris
Epicentre
Switzerland, Geneva
Medecins Sans Frontieres
Twesigye, Rogers
France, Paris
Epicentre
Bátwala, Vincent K.
Uganda, Mbarara
Mbarara University of Science and Technology
Piola, Patrice
France, Paris
Epicentre
Nabasumba, Carolyn
France, Paris
Epicentre
Kiguli, James
Uganda, Mbarara
Mbarara University of Science and Technology
Mutebi, Frederick
France, Paris
Epicentre
Hook, Christa
Switzerland, Geneva
Medecins Sans Frontieres
Guillerm, Martine
Switzerland, Geneva
Medecins Sans Frontieres
Moody, Anthony H.
Switzerland, Geneva
Medecins Sans Frontieres
Guthmann, Jean Paul
France, Paris
Epicentre
Statistics
Citations: 69
Authors: 11
Affiliations: 3
Identifiers
Doi:
10.1016/j.trstmh.2007.09.014
ISSN:
00359203
Research Areas
Health System And Policy
Infectious Diseases
Study Locations
Uganda