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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Long-term results of low-dose-rate interstitial-intracavitary brachytherapy in the treatment of carcinoma of the cervix
International Journal of Radiation Oncology Biology Physics, Volume 54, No. 1, Year 2002
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Description
Purpose: Brachytherapy plays a major role in the treatment of patients with carcinoma of the cervix. However, routine intracavitary brachytherapy may not be feasible or adequate to treat locally advanced disease. The purpose of this retrospective study (spanning a 20-year period) was to determine the outcome of interstitial low-dose-rate brachytherapy in the treatment of bulky or locally advanced cervical cancer. The long-term survival and safety of this technique were evaluated, along with its impact on local and locoregional control, disease-free survival, and complications. Methods and Materials: A total of 185 previously untreated patients with cervical cancer were treated between 1977 and 1997. According to the International Federation of Gynecology and Obstetrics classification, 21 patients had Stage IB (barrel), 77 Stage II, 77 Stage III, and 10 Stage IV disease. All patients were treated by a combination of external megavoltage irradiation to the pelvis to a dose of 5040 cGy followed by interstitial-intracavitary implants to a dose of 40-50 Gy to the implanted volume in two applications. Results: Clinical local control was achieved in 152 (82%) of the 185 patients. A 5-year disease-free survival rate of 65%, 67%, 49%, and 17% was achieved for patients with Stage IB, II, III, and IV disease, respectively. Eighteen (10%) of the 185 patients developed Radiation Therapy Oncology Group Grade 3 or 4 late complications. Conclusion: Patients with locally advanced cervical cancer, or with distorted anatomy, may be treated adequately with interstitial brachytherapy to achieve excellent locoregional control and a reasonable chance of cure with acceptable morbidity. © 2002 Elsevier Science Inc.
Authors & Co-Authors
Syed, A. M.Nisar
United States, Long Beach
Long Beach Memorial Medical Center
Puthawala, Ajmel A.
United States, Long Beach
Long Beach Memorial Medical Center
Abdelaziz, Nashwa Nazmy
United States, Long Beach
Long Beach Memorial Medical Center
Egypt, Cairo
Ain Shams University
El-Naggar, Mervat
United States, Long Beach
Long Beach Memorial Medical Center
Egypt, Giza
National Cancer Institute
DiSaia, Philip John
United States, Long Beach
Long Beach Memorial Medical Center
Berman, Michael
United States, Long Beach
Long Beach Memorial Medical Center
Tewari, Krishnansu S.
United States, Long Beach
Long Beach Memorial Medical Center
Sharma, Anil
United States, Long Beach
Long Beach Memorial Medical Center
Londrc, Adina
United States, Long Beach
Long Beach Memorial Medical Center
Juwadi, Supriya
United States, Long Beach
Long Beach Memorial Medical Center
Cherlow, Joel M.
United States, Long Beach
Long Beach Memorial Medical Center
Damore, Steven
United States, Long Beach
Long Beach Memorial Medical Center
Chen, Yi Jen
United States, Duarte
City of Hope National Med Center
Statistics
Citations: 89
Authors: 13
Affiliations: 4
Identifiers
Doi:
10.1016/S0360-3016(02)02900-0
ISSN:
03603016
Research Areas
Cancer
Study Design
Cohort Study