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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Dynamics of viremia in primary HIV-1 infection in Africans: Insights from analyses of host and viral correlates
Virology, Volume 449, Year 2014
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Description
In HIV-1 infection, plasma viral load (VL) has dual implications for pathogenesis and public health. Based on well-known patterns of HIV-1 evolution and immune escape, we hypothesized that VL is an evolving quantitative trait that depends heavily on duration of infection (DOI), demographic features, human leukocyte antigen (HLA) genotypes and viral characteristics. Prospective data from 421 African seroconverters with at least four eligible visits did show relatively steady VL beyond 3 months of untreated infection, but host and viral factors independently associated with cross-sectional and longitudinal VL often varied by analytical approaches and sliding time windows. Specifically, the effects of age, HLA-B*53 and infecting HIV-1 subtypes (A1, C and others) on VL were either sporadic or highly sensitive to time windows. These observations were strengthened by the addition of 111 seroconverters with 2-3 eligible VL results, suggesting that DOI should be a critical parameter in epidemiological and clinical studies. © 2013 Elsevier Inc.
Authors & Co-Authors
Prentice, Heather A.
United States, Birmingham
Department of Epidemiology
Price, Matt A.
United States, New York
International Aids Vaccine Initiative
United States, San Francisco
University of California, San Francisco
Porter, Travis R.
United States, Birmingham
Department of Epidemiology
Cormier, Emmanuel G.
United Kingdom, London
Chelsea and Westminster Hospital
Netherlands, Leiden
Crucell nv
Mugavero, Michael J.
United States, Birmingham
The University of Alabama at Birmingham
Kamali, Anatoli
Uganda
Mrc/uvri Uganda Virus Research Unit on Aids
Karita, Etienne
Rwanda, Kigali
Projet San Francisco
Lakhi, Shabir
Zambia, Lusaka
Zambia-emory Hiv Research Project
Sanders, Eduard Joachim
Kenya, Kilifi
Centre for Geographic Medicine Research
United Kingdom, Oxford
University of Oxford
Anzala, Aggrey Omu
Kenya, Nairobi
Kenya Aids Vaccine Initiative Kavi
Amornkul, Pauli N.
United States, New York
International Aids Vaccine Initiative
Allen, Susan A.
Zambia, Lusaka
Zambia-emory Hiv Research Project
United States, Atlanta
Emory University
Hunter, Eric
United States, Atlanta
Emory University
Kaslow, Richard A.
United States, Birmingham
Department of Epidemiology
United States, Washington, D.c.
U.s. Department of Veterans Affairs
Gilmour, Jill W.
United Kingdom, London
Chelsea and Westminster Hospital
Tang, Jianming
United States, Birmingham
Department of Epidemiology
United States, Birmingham
The University of Alabama at Birmingham
Statistics
Citations: 16
Authors: 16
Affiliations: 14
Identifiers
Doi:
10.1016/j.virol.2013.11.024
ISSN:
00426822
e-ISSN:
10960341
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative