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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Gingerenone A Attenuates Monocyte-Endothelial Adhesion via Suppression of I Kappa B Kinase Phosphorylation
Journal of Cellular Biochemistry, Volume 119, No. 1, Year 2018
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Description
During the early stages of atherosclerosis, monocytes bind and migrate into the endothelial layer, promoting inflammation within the aorta. In order to prevent the development of atherosclerosis, it is critical to inhibit such inflammation. The therapeutic effects of ginger have been investigated in several models of cardiovascular disease. However, although a number of previous studies have focused on specific compounds, the mechanisms of action responsible remain unclear. Here, we investigated five major compounds present in ginger, and observed that gingerenone A exhibited the strongest inhibitory effects against tumor necrosis factor (TNF)-α and lipopolysaccharide (LPS) induced monocyte-endothelial adhesion. Furthermore, gingerenone A significantly suppressed the expression of TNF-α and LPS-induced vascular cell adhesion molecule-1 (VCAM-1) and chemokine (C-C motif) ligand 2 (CCL2), key mediators of the interaction between monocytes, and endothelial cells. Transactivation of nuclear factor-κB (NF-κB), which is a key transcription factor of VCAM-1 and CCL2, was induced by TNF-α and LPS, and inhibited by treatment of gingerenone A. Gingerenone A also inhibited the phosphorylation of NF-κB inhibitor (IκB) α and IκB Kinase. Taken together, these results demonstrate that gingerenone A attenuates TNF-α and LPS-induced monocyte adhesion and the expression of adhesion factors in endothelial cells via the suppression of NF-κB signaling. J. Cell. Biochem. 119: 260–268, 2018. © 2017 Wiley Periodicals, Inc.
Authors & Co-Authors
Kim, Hee Joo
South Korea, Seoul
Department of Food and Animal Biotechnology
Son, Joe Eun
South Korea, Seoul
Department of Food and Animal Biotechnology
South Korea, Seoul
Graduate School of Convergence Science and Technology
Kim, Jae Hwan
South Korea, Seoul
Department of Food and Animal Biotechnology
Lee, Charles C.
United States, Ithaca
Cornell University
Yang, Hee
South Korea, Seoul
Department of Food and Animal Biotechnology
South Korea, Seoul
Graduate School of Convergence Science and Technology
Yaghmoor, Soonham Sami
Saudi Arabia, Jeddah
King Abdulaziz University
Ahmed, Y. M.
Saudi Arabia, Jeddah
King Abdulaziz University
Yousef, Jehad Mustafa
Saudi Arabia, Jeddah
King Abdulaziz University
Abualnaja, Khalid Omer
Saudi Arabia, Jeddah
King Abdulaziz University
al-Malki, Abdulrahman Labeed
Saudi Arabia, Jeddah
King Abdulaziz University
Kumosani, Taha Abdullah
Saudi Arabia, Jeddah
King Abdulaziz University
Kim, Jong Hun
South Korea, Seoul
Seoul National University
Yoon Park, Jung Han
South Korea, Seoul
Seoul National University
Lee, Changyong
United States, Ithaca
Cornell University
Saudi Arabia, Jeddah
King Abdulaziz University
Kim, Jong Eun
South Korea, Seoul
Dongguk University, Seoul
Lee, Kiwon
South Korea, Seoul
Department of Food and Animal Biotechnology
South Korea, Seoul
Graduate School of Convergence Science and Technology
South Korea, Seoul
Seoul National University
Statistics
Citations: 16
Authors: 16
Affiliations: 6
Identifiers
Doi:
10.1002/jcb.26138
ISSN:
07302312
e-ISSN:
10974644
Research Areas
Cancer
Noncommunicable Diseases