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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Facile transformation of Biginelli pyrimidin-2(1H)-ones to pyrimidines. In vitro evaluation as inhibitors of Mycobacterium tuberculosis and modulators of cytostatic activity
European Journal of Medicinal Chemistry, Volume 46, No. 6, Year 2011
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Description
A series of pyrimidine derivatives bearing amine substituents at C-2 position were obtained from Biginelli 3,4-dihydropyrimidin-2(1H)-ones and the effect of structural variation on anti-TB activity against Mycobacterium tuberculosis H37Rv strain and antiviral activity in a series of cell cultures was evaluated. While the compounds were found to possess structure dependent cytostatic activity, these were not found to be efficient inhibitors of M. tuberculosis nor did they inhibit a broad variety of DNA or RNA viruses in cell culture. © 2011 Elsevier Masson SAS.
Authors & Co-Authors
Singh, Kamajit Shanker
India, Amritsar
Guru Nanak Dev University
Singh, Kawaljit
India, Amritsar
Guru Nanak Dev University
Wan, Baojie
United States, Chicago
University of Illinois at Chicago
Franzblau, Scott Gary
United States, Chicago
University of Illinois at Chicago
Chibale, Kelly
South Africa, Cape Town
University of Cape Town
Balzarini, Jan M.
Belgium, Leuven
Rega Institute for Medical Research
Statistics
Citations: 70
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1016/j.ejmech.2011.03.010
ISSN:
02235234
e-ISSN:
17683254
Research Areas
Genetics And Genomics
Infectious Diseases