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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Evidence of an x-linked or recessive genetic component to prostate cancer risk
Nature Medicine, Volume 1, No. 8, Year 1995
Notification
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Description
We used data from a population-based cohort study of blacks, Hispanics, Japanese and whites to examine the frequency of prevalent prostate and breast cancer by family history status of first-degree relatives (parents and siblings). Independent of race, the age-adjusted relative risk for prevalent prostate cancer in subjects with affected brothers was approximately two times that in subjects with affected fathers (P< 0.00005). No such excess risk for breast cancer was observed among subjects with affected sisters compared to those with affected mothers (age- and race-adjusted relative risk = 1.10, P = 0.34). The magnitude of the relative risk for prostate cancer in sibling- versus parent-affected groups was significantly different from that of the comparable relative risk for breast cancer (P < 0.00005). An excess risk of prostate cancer in men with affected brothers compared to those with affected fathers is consistent with the hypothesis of an X-linked, or recessive, model of inheritance. © 1995 Nature Publishing Group.
Authors & Co-Authors
Monroe, Kristine R.
United States, Los Angeles
Keck School of Medicine of Usc
Yu, Mimi C.
United States, Los Angeles
Keck School of Medicine of Usc
Kolonel, Laurence N.
United States, Honolulu
University of Hawaiʻi at Mānoa
Coetzee, Gerhard A.
United States, Los Angeles
Keck School of Medicine of Usc
Wilkens, Lynne Ross
United States, Honolulu
University of Hawaiʻi at Mānoa
Henderson, Brian E.
United States, Los Angeles
Keck School of Medicine of Usc
Statistics
Citations: 183
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1038/nm0895-827
ISSN:
10788956
Research Areas
Cancer
Genetics And Genomics
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Participants Gender
Male