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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Hepatitis C virus genotypes in north eastern Algeria: A retrospective study
World Journal of Hepatology, Volume 5, No. 7, Year 2013
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Description
AIM: To determine the frequency of various hepatitis C virus (HCV) genotypes present in patients from north eastern Algeria. METHODS: This is a retrospective cross-sectional study of 435 HCV infected patients from northeast Algeria, detected in the Sadelaoud laboratory and diagnosed between January 2010 and December 2012. The patients were diagnosed with HCV infection in their local hospitals and referred to be assessed for HCV genotype before the antiviral treatment. Demographic information (sex, age and address), genotype, subtype and viral load were retrieved from the patient medical records. The serum samples were tested by the type-specific genotyping assay. RESULTS: The majority of the patients (82.5%) were from the central part of the examined region (P = 0.002). The mean age of the patients studied was 53.6 ± 11.5 years. HCV genotype 1 was the most frequent (88.7%), followed by genotypes 2 (8.5%), 4 (1.1%), 3 (0.9%) and 5 (0.2%). Genotype 6 was not detected in these patients. Mixed infection across the HCV subtypes was detected in twenty patients (4.6%). The genotype distribution was related to age and region. Genotype 1 was significantly less frequent in the ≥ 60 age group than in the younger age group (OR = 0.2; 95%CI: 0.1-0.5, P < 0.001). Furthermore, genotype 1 was more frequent in the central part of the examined region than elsewhere (P < 0.01). CONCLUSION: The HCV genotype (type 1b was dominant) distribution in Algeria is different from those in other northern countries of Africa. © 2013 Baishideng.
Authors & Co-Authors
Rouabhia, Samir
Algeria, Batna
Centre Hospitalo-universitaire Touhami Benflis - Batna
Sadelaoud, Mourad
Algeria, Batna
Sadelaoud Laboratory of Medical Biology
Chaabna, Karima
France, Lyon
Centre International de Recherche Sur le Cancer
Toumi, Wided
Algeria, Batna
Sadelaoud Laboratory of Medical Biology
Abenavoli, Ludovico
Italy, Catanzaro
Università Degli Studi Magna Graecia Di Catanzaro
Statistics
Citations: 26
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.4254/wjh.v5.i7.393
e-ISSN:
19485182
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Algeria