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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
High prevalence of unique recombinant forms of HIV-1 in Ghana: Molecular epidemiology from an antiretroviral resistance study
Journal of Acquired Immune Deficiency Syndromes, Volume 48, No. 5, Year 2008
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Description
BACKGROUND: In Ghana, programs to expand antiretroviral access are being implemented. In this context, the dynamic genetic evolution of HIV-1 requires continuous surveillance, particularly when diverse genetic forms co-circulate. METHODS:: Phylogenetic and antiretroviral resistance analyses of HIV-1 partial pol sequences from plasma RNA samples from 207 Ghanaian individuals were performed. RESULTS:: 66% of infections were CRF02-AG, whereas 25% were unique recombinant forms (URFs). All 52 URFs were characterized by bootscanning. CRF02-AG was parental strain in 87% of URFs, forming recombinants with genetic forms circulating in minor proportions: CRF06-cpx, sub-subtype A3, CRF09-cpx and subtypes G and D. Two triple recombinants (CRF02-AG/A3/CRF06-cpx and CRF02-AG/A3/CRF09-cpx) were identified. Antiretroviral resistance analyses revealed that six individuals, five of which were antiretroviral drug-experienced, harbored mutations conferring high level of resistance to reverse transcriptase inhibitors. No major resistance mutations were identified in the protease, although insertions of one and three amino acids were detected. CONCLUSIONS:: The high frequency of URFs detected probably reflects a significant incidence of coinfections or superinfections with diverse viral strains, which increases the genetic complexity of the HIV-1 epidemic in West Africa. Monitoring of HIV-1 drug resistance might provide data on the implications of intersubtype recombination in response to antiretrovirals. © 2008 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Delgado, Elena
Spain, Majadahonda
Centro Nacional de Microbiologia
Ampofo, William Kwabena
Ghana, Accra
University of Ghana
Sierra, María
Spain, Majadahonda
Centro Nacional de Microbiologia
Torpey, Kwasi E.
Ghana, Accra
Public Health Specialist
Pérez-Alvárez, Lucía
Spain, Majadahonda
Centro Nacional de Microbiologia
Bonney, Evelyn Yayra A.
Ghana, Accra
University of Ghana
Mukadi, Ya Diul
United States, Durham
Fhi 360
Lartey, Margaret Yaa
Ghana, Accra
University of Ghana
Nyarko, Charles
Ghana
St. Martin de Porres Hospital
Amenyah, Richard Noamesi
Ghana, Accra
Public Health Specialist
Thomson, Michael M.
Spain, Majadahonda
Centro Nacional de Microbiologia
Nájera, Raphael
Spain, Majadahonda
Centro Nacional de Microbiologia
Statistics
Citations: 38
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1097/QAI.0b013e3181806c0e
ISSN:
15254135
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Multi-countries
Ghana