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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Antibodies against mycobacterial proteins as biomarkers for HIV-associated smear-negative tuberculosis
Clinical and Vaccine Immunology, Volume 21, No. 6, Year 2014
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Description
Serology data are limited for patients with sputum smear-negative HIV-associated active tuberculosis (TB). We evaluated the serum antibody responses against the mycobacterial proteins MPT51, MS, and echA1 and the 38-kDa protein via enzyme-linked immunosorbent assay (ELISA) in South African (S.A.) HIV-positive (HIV+) smear-negative TB patients (n = 56), U.S. HIV+ controls with a positive tuberculin skin test (TST+; n = 21), and S.A. HIV-negative (HIV-) (n = 18) and HIV+ (n = 24) controls. TB patients had positive antibody reactivity against MPT51 (73%), echA1 (59%), MS (36%), and the 38-kDa protein (11%). Little reactivity against MPT51 and echA1 was observed in control groups at low risk for TB, i.e., S.A. HIV- (0% and 6%, respectively), and at moderate risk for TB development, i.e., U.S. HIV+ TST+ controls (14% and 10%, respectively). By contrast, more reactivity was detected in the S.A. HIV + control group at higher risk for TB (25% and 45%, respectively). Our data hold promise that antibody detection against MPT51 and echA1 might have adjunctive value in the detection of HIV+ smear-negative TB and might reflect increasing Mycobacterium tuberculosis infection activity in asymptomatic HIV+ individuals. Copyright © 2014, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Siev, Michael
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Wilson, Douglas P.K.
South Africa, Pietermaritzburg
Edendale Hospital
Kainth, Supreet
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Kasprowicz, Victoria O.
United States, Cambridge
Massachusetts Institute of Technology
South Africa, Durban
The Nelson R. Mandela Medical School
Feintuch, Catherine Manix
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Jenny-Avital, Elizabeth R.
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Achkar, Jacqueline M.
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Statistics
Citations: 13
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1128/CVI.00805-13
ISSN:
15566811
e-ISSN:
1556679X
Research Areas
Infectious Diseases
Study Design
Randomised Control Trial