Gut resistome after oral antibiotics in preschool children in Burkina Faso: A randomized, controlled trial
Clinical Infectious Diseases, Volume 70, No. 3, Year 2020
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We evaluated the effect of systemic antibiotics (azithromycin, amoxicillin, cotrimoxazole, or placebo) on the gut resistome in children aged 6 to 59 months. Azithromycin and cotrimoxazole led to an increase in macrolide and sulfonamide resistance determinants. Resistome expansion can be induced with a single course of antibiotics.