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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effects of telmisartan on glucose levels in people at high risk for cardiovascular disease but free from diabetes: The TRANSCEND study
Diabetes Care, Volume 34, No. 9, Year 2011
Notification
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Description
OBJECTIVE - Several large clinical trials suggest that ACE inhibitors may reduce the incidence of diabetes. Less is known about the effects of angiotensin receptor blockers (ARBs) on reducing incident diabetes or leading to regression of impaired fasting glucose (IFG) or impaired glucose tolerance (IGT) to normoglycemia. RESEARCH DESIGN AND METHODS - Participants were 3,488 adults at high risk for cardiovascular disease but free from diabetes (mean age 67 years; 61% male) in the Telmisartan Randomized Assessment Study in ACE Intolerant Subjects With Cardiovascular Disease (TRANSCEND) study. The participants were randomized to the ARB telmisartan 80 mg (n = 1,726) or placebo (n = 1,762) in addition to usual care. RESULTS - During a median 56 months, 21.8% of participants treated with telmisartan and 22.4%of those on placebo developed diabetes (relative ratio 0.95 [95%CI 0.83-1.10]; P = 0.51). Participants originally diagnosed with IFG and/or IGT were equally likely to regress to normoglycemia (26.9 vs. 24.5%) or to progress to incident diabetes (20.1 vs. 21.1%; P = 0.59) on telmisartan or placebo. CONCLUSIONS - There was no evidence that addition of the ARB telmisartan to usual care prevents incident diabetes or leads to regression of IFG or IGT in people at high risk for cardiovascular disease but free from diabetes. © 2011 by the American Diabetes Association.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3161302/bin/supp_34_9_1902__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3161302/bin/supp_dc11-0545v110545_DC110545SupplementaryData.pdf
Authors & Co-Authors
Barzilay, Joshua I.
United States, Atlanta
Emory University School of Medicine
Gao, Peggy
Canada, Hamilton
Population Health Research Institute, Ontario
Ryde´n, Lårs E.
Sweden, Stockholm
Karolinska Universitetssjukhuset
Schumacher, Helmut
Germany, Ingelheim am Rhein
Boehringer Ingelheim International Gmbh
Probstfield, Jeffrey L.
United States, Seattle
University of Washington School of Medicine
Commerford, Patrick Joseph
South Africa, Cape Town
University of Cape Town
Dans, Antonio L.L.
Philippines, Manila
Philippine General Hospital
Ferreira, Rafael
Portugal, Amadora
Praceta do Comercio
Keltai, Mátyás
Hungary, Budapest
Semmelweis Egyetem
Paolasso, Ernesto Andrés C.
Argentina, Rosario
Estudios Clínicos Latinoamérica
Yusuf, Salim N.
Canada, Hamilton
Population Health Research Institute, Ontario
Teo, Koonkang
Canada, Hamilton
Population Health Research Institute, Ontario
Statistics
Citations: 18
Authors: 12
Affiliations: 10
Identifiers
Doi:
10.2337/dc11-0545
ISSN:
01495992
e-ISSN:
19355548
Research Areas
Noncommunicable Diseases
Study Design
Cohort Study
Participants Gender
Male