Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
African 2, a clonal complex of Mycobacterium bovis epidemiologically important in East Africa
Journal of Bacteriology, Volume 193, No. 3, Year 2011
Notification
URL copied to clipboard!
Description
We have identified a clonal complex of Mycobacterium bovis isolated at high frequency from cattle in Uganda, Burundi, Tanzania, and Ethiopia. We have named this related group of M. bovis strains the African 2 (Af2) clonal complex of M. bovis. Af2 strains are defined by a specific chromosomal deletion (RDAf2) and can be identified by the absence of spacers 3 to 7 in their spoligotype patterns. Deletion analysis of M. bovis isolates from Algeria, Mali, Chad, Nigeria, Cameroon, South Africa, and Mozambique did not identify any strains of the Af2 clonal complex, suggesting that this clonal complex of M. bovis is localized in East Africa. The specific spoligotype pattern of the Af2 clonal complex was rarely identified among isolates from outside Africa, and the few isolates that were found and tested were intact at the RDAf2 locus. We conclude that the Af2 clonal complex is localized to cattle in East Africa. We found that strains of the Af2 clonal complex of M. bovis have, in general, four or more copies of the insertion sequence IS6110, in contrast to the majority of M. bovis strains isolated from cattle, which are thought to carry only one or a few copies. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3021238/bin/supp_193_3_670__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3021238/bin/supp_193_3_670__Submit_Af2__Supplementary_resubmission_Final.zip
Authors & Co-Authors
Berg, Stefan
United Kingdom, Addlestone
Animal and Plant Health Agency
García-Pelayo, M. Carmen
United Kingdom, Addlestone
Animal and Plant Health Agency
Müller, Borna
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Hailu, Elena
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Asiimwe, Benon Byamugisha
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Kremer, Kristin
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Dale, James
United Kingdom, Addlestone
Animal and Plant Health Agency
Boniotti, Maria Beatrice
Italy, Brescia
Istituto Zooprofilattico Sperimentale Della Lombardia e Dell'emilia Romagna Bruno Ubertini
Rodriguez-Campos, Sabrina
Spain, Madrid
Universidad Complutense de Madrid
Hilty, Markus
Switzerland, Bern
University of Bern
Rigouts, Leen
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
South Africa, Pretoria
University of Pretoria
Firdessa, Rebuma
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
MacHado, Adelina Da Conceicao
Mozambique, Maputo
Universidade Eduardo Mondlane
Mucavele, Custodia
South Africa, Onderstepoort
Onderstepoort Veterinary Institute
Ngandolo, Bongo Naré Richard
Chad
Laboratoire de Recherches Vétérinaires et Zootechniques de Farcha
Bruchfeld, Judith
Sweden, Stockholm
Karolinska Universitetssjukhuset
Boschiroli, Laura
Italy, Brescia
Istituto Zooprofilattico Sperimentale Della Lombardia e Dell'emilia Romagna Bruno Ubertini
France, Maisons-alfort
Afssa Agence Française de Sécurité Sanitaire Des Aliments
Müller, Annélle
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Sahraoui, Naima
Algeria, Blida
Université Blida 1
Pacciarini, Maria Lodovica
Italy, Brescia
Istituto Zooprofilattico Sperimentale Della Lombardia e Dell'emilia Romagna Bruno Ubertini
Cadmus, Simeon Idowu Babalola
Nigeria, Ibadan
University of Ibadan
Joloba, Moses Lutaakome
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
van Soolingen, Dick
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Michel, Anita Luise
South Africa, Pretoria
University of Pretoria
DjØnne, Berit Kristoffersen
Norway, Oslo
Veterinærinstituttet
Aranaz, Alicia
Spain, Madrid
Universidad Complutense de Madrid
Zinsstag, Jakob B.
Sweden, Stockholm
Södersjukhuset
Van Helden, Paul D.
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Portaels, Françoise Ç.Oise
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Kazwala, Rudovick Reuben
Tanzania, Morogoro
Sokoine University of Agriculture
Källenius, Gunilla
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Hewinson, R. Glyn
United Kingdom, Addlestone
Animal and Plant Health Agency
Aseffa, Abraham
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Gordon, Stephen V.
Ireland, Dublin
University College Dublin
Smith, Noel H.
United Kingdom, Addlestone
Animal and Plant Health Agency
United Kingdom, Brighton
University of Sussex
Statistics
Citations: 97
Authors: 35
Affiliations: 23
Identifiers
Doi:
10.1128/JB.00750-10
ISSN:
00219193
Study Locations
Multi-countries
Algeria
Burundi
Cameroon
Chad
Ethiopia
Mali
Mozambique
Nigeria
South Africa
Tanzania
Uganda