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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: Implications for vaccine design
Journal of Virology, Volume 86, No. 8, Year 2012
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Description
Plasma from a small subset of subjects chronically infected with HIV-1 shows remarkable magnitude and breadth of neutralizing activity. From one of these individuals (CH0219), we isolated two broadly neutralizing antibodies (bnAbs), CH01 and VRCCH31, from two clonal lineages of memory B cells with distinct specificities (variable loop 1 and 2 [V1V2] conformational specificity and CD4-binding site specificity, respectively) that recapitulate 95% of CH0219 serum neutralization breadth. These data provide proof of concept for an HIV-1 vaccine that aims to elicit bnAbs of multiple specificities. © 2012, American Society for Microbiology.
Authors & Co-Authors
Bonsignori, Mattia
Unknown Affiliation
Montefiori, David Charles
Unknown Affiliation
Wu, Xueling
Unknown Affiliation
Chen, Xi
Unknown Affiliation
Hwang, Kwanki
Unknown Affiliation
Tsao, Chun Yen
Unknown Affiliation
Kozink, Daniel M.
Unknown Affiliation
Parks, Robert J.
Unknown Affiliation
Tomaras, Georgia D.
Unknown Affiliation
Crump, John A.
Unknown Affiliation
Kapiga, Saidi Hussein
Unknown Affiliation
Sam, Noel E.
Unknown Affiliation
Kwong, Peter D.
Unknown Affiliation
Kepler, Thomas B.
Unknown Affiliation
Liao, Huaxin
Unknown Affiliation
Mascola, John R.
Unknown Affiliation
Haynes, Barton F.
Unknown Affiliation
Statistics
Citations: 17
Authors: 17
Affiliations: 9
Identifiers
Doi:
10.1128/JVI.07163-11
ISSN:
0022538X
e-ISSN:
10985514
Research Areas
Infectious Diseases