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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A phase IIa trial of the new tuberculosis vaccine, MVA85A, in HIV- and/or Mycobacterium tuberculosis-infected adults
American Journal of Respiratory and Critical Care Medicine, Volume 185, No. 7, Year 2012
Notification
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Description
Rationale: Novel tuberculosis (TB) vaccines should be safe and effective in populations infected with Mycobacterium tuberculosis (M.tb) and/or HIV for effective TB control. Objective: To determine the safety and immunogenicity of MVA85A, a novel TB vaccine, among M.tb- and/or HIV-infected persons in a setting where TB and HIV are endemic. Methods: An open-label, phase IIa trial was conducted in 48 adults with M.tb and/or HIV infection. Safety and immunogenicity were analyzed up to 52 weeks after intradermal vaccination with 5 × 10 7plaque-forming units of MVA85A. Specific T-cell responses were characterizedby IFN-γ enzyme-linked immunospot and whole blood intracellular cytokine staining assays. Measurements and Main Results: MVA85A was well tolerated and no vaccine-related serious adverse events were recorded. MVA85A induced robust and durable response of mostly polyfunctional CD4 +T cells, coexpressing IFN-γ, tumor necrosis factor-α, and IL-2. Magnitudes of pre- and postvaccination T-cell responses were lower in HIV-infected, compared with HIV-uninfected, vaccinees. No significant effect of antiretroviral therapy on immunogenicity of MVA85A was observed. Conclusions: MVA85A was safe and immunogenic in persons with HIV and/or M.tb infection. These results support further evaluation of safety and efficacy of this vaccine for prevention of TB in these target populations. Copyright © 2012 by the American Thoracic Society.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3326425/bin/supp_185_7_769__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3326425/bin/supp_185.7.769_201108-1548OC.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3326425/bin/supp_185_7_769_v2_index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3326425/bin/supp_185.7.769_Scriba_ODS.pdf
Authors & Co-Authors
Scriba, Thomas J.
South Africa, Cape Town
University of Cape Town
Tameris, Michele D.
South Africa, Cape Town
University of Cape Town
Smit, Erica
South Africa, Cape Town
University of Cape Town
van der Merwe, Linda
South Africa, Cape Town
University of Cape Town
Hughes, Elizabeth Jane
South Africa, Cape Town
University of Cape Town
Kadira, Blessing
South Africa, Cape Town
University of Cape Town
Mauff, Katya A.L.
South Africa, Cape Town
University of Cape Town
Moyo, Sizulu
South Africa, Cape Town
University of Cape Town
Brittain, Nathaniel J.
United Kingdom, Oxford
University of Oxford
Lawrie, Alison M.
United Kingdom, Oxford
University of Oxford
Mulenga, Humphrey
South Africa, Cape Town
University of Cape Town
de Kock, Marwou
South Africa, Cape Town
University of Cape Town
Makhethe, Lebohang
South Africa, Cape Town
University of Cape Town
Van Rensburg, Esme Janse
South Africa, Cape Town
University of Cape Town
Gelderbloem, Sebastian J.
South Africa, Rondebosch
Aeras
Veldsman, Ashley
South Africa, Cape Town
University of Cape Town
Hatherill, Mark
South Africa, Cape Town
University of Cape Town
Geldenhuys, Hennie D.
South Africa, Cape Town
University of Cape Town
Hill, Adrian V. S.
United Kingdom, Oxford
University of Oxford
Hawkridge, Anthony J.
South Africa, Cape Town
University of Cape Town
Hussey, Greg Dudley
South Africa, Cape Town
University of Cape Town
Hanekom, Willem Albert
South Africa, Cape Town
University of Cape Town
McShanez, Helen
United Kingdom, Oxford
University of Oxford
Mahomed, Hassan
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 77
Authors: 24
Affiliations: 3
Identifiers
Doi:
10.1164/rccm.201108-1548OC
ISSN:
1073449X
Research Areas
Cancer
Infectious Diseases