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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Ketoacidosis at presentation of type 1 diabetes in children in Kuwait: Frequency and clinical characteristics
Pediatric Diabetes, Volume 11, No. 5, Year 2010
Notification
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Description
Background: Diabetic ketoacidosis (DKA) has significant morbidity and mortality, and is common at diagnosis in children. Objective: Describe the frequency and severity of DKA at diagnosis of type 1 diabetes mellitus (T1DM) in children in Kuwait. Methods: Hospital records of 677 diabetic children less than 12 yr of age, diagnosed during the period of 2000-2006 were reviewed. DKA was defined as blood glucose > 11 mmol/L, pH < 7.3, and/or bicarbonate < 15 mmol/L with ketonuria. Results: Of all patients diagnosed with T1DM, 255 (37.7%) presented with DKA. The frequency of DKA was constant between 2000 and 2002 (42.7-41.5%), but decreased in the following years to 30.7% in 2006 (p < 0.005). The majority had either mild or moderate DKA (74.1%). Fifty-one (36.7%) of all children in the 0-4 yr had severe DKA compared to ten (2.9%) in the 5- to 8-yr-old group, and three (1.5%) in 9- to 12-yr-old patients (p < 0.0001). Moreover, 83% of children with severe DKA were in the 0-4 yr age group. One child (0.15%) died and twenty-seven (4%) needed intensive care unit (ICU) care. Conclusion: Our study provides recent data on Middle Eastern population, for whom data are sparse. Although it has significantly decreased, the frequency of DKA at presentation of T1DM in children in Kuwait is still high, secondary to the high prevalence of diabetes in the community. Young children, especially those less than 2 yr old remain at high risk. Increasing the general awareness of the public as well as of pediatricians to the disease may lead to early diagnosis before the development of acidosis. © 2009 John Wiley & Sons A/S.
Authors & Co-Authors
Abdul-Rasoul, Majedah M.
Kuwait, Kuwait City
Mubarak Alkabeer Hospital
Al-Mahdi, M.
Kuwait, Hadiya
Adan Hospital
Al-Qattan, H.
Kuwait, Hadiya
Adan Hospital
Al-Tarkait, N.
Kuwait
Al-sabah Hospital
Alkhouly, Mohamed
Kuwait, Safat
Farwania Hospital
Al-Safi, R.
Kuwait, Kuwait City
Mubarak Alkabeer Hospital
Al-Shawaf, F.
Kuwait, Kuwait City
Mubarak Alkabeer Hospital
Mahmoud, H.
Kuwait, Kuwait City
Jahra Hospital
Statistics
Citations: 53
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1111/j.1399-5448.2009.00600.x
ISSN:
1399543X
e-ISSN:
13995448
Research Areas
Health System And Policy
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cross Sectional Study