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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Transcription factor FOXO3a controls the persistence of memory CD4 + T cells during HIV infection
Nature Medicine, Volume 14, No. 3, Year 2008
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Description
The persistence of central memory CD4+ T cells (TCM cells) is a major correlate of immunological protection in HIV/AIDS, as the rate of TCM cell decline predicts HIV disease progression. In this study, we show that TCM cells and effector memory CD4+ T cells (TEM cells) from HIV+ elite controller (EC) subjects are less susceptible to Fas-mediated apoptosis and persist longer after multiple rounds of T cell receptor triggering when compared to TCM and T EM cells from aviremic successfully treated (ST) subjects or from HIV- donors. We show that persistence of TCM cells from EC subjects is a direct consequence of inactivation of the FOXO3a pathway. Silencing the transcriptionally active form of FOXO3a by small interfering RNA or by introducing a FOXO3a dominant-negative form (FOXO3a Nt) extended the long-term survival of TCM cells from ST subjects to a length of time similar to that of TCM cells from EC subjects. The crucial role of FOXO3a in the survival of memory cells will help shed light on the underlying immunological mechanisms that control viral replication in EC subjects. © 2008 Nature Publishing Group.
Authors & Co-Authors
Procopio, Francesco Andrea
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Canada, Montreal
University of Montreal
He, Zhong
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Canada, Montreal
University of Montreal
Chomont, Nicolas
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Canada, Montreal
University of Montreal
Riou, Catherine
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Zhang, Yuwei
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Canada, Montreal
University of Montreal
Boucher, Genèvieve
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Wilkinson, Peter A.
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Shi, Yu
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Canada, Montreal
University of Montreal
Said, Elias Anthony
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Canada, Montreal
University of Montreal
Trautmann, Lydie
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Canada, Montreal
University of Montreal
Boulassel, Mohamed Rachid
Canada, Montreal
Université Mcgill
Routy, Jean Pierre G.
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Canada, Montreal
Université Mcgill
Haddad, Elias K.
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Canada, Montreal
University of Montreal
Canada, Montreal
Université Mcgill
Seḱaly, Rafick Pierre
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Canada, Montreal
University of Montreal
Canada, Montreal
Université Mcgill
Statistics
Citations: 152
Authors: 14
Affiliations: 4
Identifiers
Doi:
10.1038/nm1728
ISSN:
1546170X
Research Areas
Cancer
Infectious Diseases