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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Oesophageal varices, schistosomiasis, and mortality among patients admitted with haematemesis in Mwanza, Tanzania: A prospective cohort study
BMC Infectious Diseases, Volume 14, No. 1, Article 303, Year 2014
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Description
Background: Upper gastrointestinal bleeding (UGIB) is a common cause of hospital admissions worldwide. Aetiologies vary by sociodemographics and geography. Retrospective studies of endoscopies in much of Africa have documented oesophageal varices as a leading cause of UGIB. Prospective studies describing outcomes and associations with clinical factors are lacking.Methods: We conducted a prospective cohort study at a referral hospital in Mwanza, Tanzania where schistosomiasis is endemic. Adults admitted with haematemesis underwent laboratory workup, schistosomiasis antigen testing and elective endoscopy, and were followed for two months for death or re-bleeding. We assessed predictors of endoscopic findings using logistic regression models, and determined prediction rules that maximised sensitivity and positive predictive value (PPV).Results: Of 124 enrolled patients, 13 died within two months (10%); active schistosomiasis prevalence was 48%. 64/91(70%) patients had oesophageal varices. We found strong associations between varices and numerous demographic or clinical findings, permitting construction of simple, high-fidelity prediction rules for oesophageal varices applicable even in rural settings. Portal vein diameter ≥ 13 mm or water sourced from the lake yielded sensitivity, specificity, PPV and NPV > 90% for oesophageal varices; presence of splenomegaly or water sourced from the lake maintained sensitivity and PPV > 90%.Conclusions: Our results guide identification of patients, via ultrasound and clinical examination, likely to have varices for whom referral for endoscopy may be life-saving. Furthermore, they support empiric anti-schistosome treatment for patients with UGIB in schistosome-endemic regions. These interventions have potential to reduce UGIB-related morbidity and mortality in Africa. © 2014 Chofle et al.; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4065539/bin/1471-2334-14-303-S1.pdf
Authors & Co-Authors
Chofle, Awilly A.
Unknown Affiliation
Jaka, Hyasinta M.
Unknown Affiliation
Koy, Mheta
Unknown Affiliation
Smart, Luke R.
Unknown Affiliation
Kabangila, Rodrick
Unknown Affiliation
Ewings, Fiona M.
Unknown Affiliation
Mazigo, Humphrey Deogratias
Unknown Affiliation
Johnson, Warren D.
Unknown Affiliation
Fitzgerald, Daniel W.
Unknown Affiliation
Peck, Robert N.
Unknown Affiliation
Downs, Jennifer Alzos
Unknown Affiliation
Statistics
Citations: 30
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1186/1471-2334-14-303
e-ISSN:
14712334
Research Areas
Environmental
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Tanzania