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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Rotavirus strains circulating in Africa during 1996-1999: Emergence of G9 strains and P[6] strains
Vaccine, Volume 21, No. 5-6, Year 2003
Notification
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Description
Rotavirus infection is associated with 150,000-200,000 deaths annually in Africa. Although the withdrawal of the RotaShield® vaccine has been a major setback in rotavirus vaccine development, new vaccine candidates are under development and approaching phase II and III trials. Before these trials could be conducted in Africa, a comprehensive survey of the circulating VP7 serotypes and VP4 genotypes is required. During the past 3 years, over 3000 rotavirus-positive specimens from several African countries have been analysed. RT-PCR techniques for the VP7 and VP4 genotypes and by monoclonal antibodies to the VP6 subgroup and VP7 serotype have been performed. Almost 75% of the strains were typed by the VP7 monoclonal antibodies or RT-PCR. VP4 genotyping was done in approximately half of these strains. The predominant strains circulating across Africa during 1996-1999 were P[6]G1 and P[6]G3 strains. Geographic differences were noted and West Africa displayed the most diverse strains with G3/8 and G1/3 "mosaic" viruses occurring commonly. G9 strains were identified in several countries indicating that the strain is emerging in Africa too. G9 was the predominant strain in certain countries during 1999. The circulating types observed will have implications for the new rotavirus vaccine candidates. © 2002 Elsevier Science Ltd. All rights reserved.
Authors & Co-Authors
Steele, Andrew Duncan
South Africa, Tygerberg
South African Medical Research Council
Ivanoff, Bernard N.
Switzerland, Geneva
Organisation Mondiale de la Santé
Armah, George Enyimah
Unknown Affiliation
Akran, Véronique
Unknown Affiliation
Audu, Rosemary Ajuma
Unknown Affiliation
Esona, Mathew Dioh
Unknown Affiliation
Mbida, André Dieudonné
Unknown Affiliation
Mngara, Julius T.
Tanzania, Tanga
National Institute for Medical Research Tanga
Mwenda, Jason Mathiu
Unknown Affiliation
Muyanga, Jubra
Unknown Affiliation
Nimzing, Lohya
Unknown Affiliation
Nyangao, James W.O.
Unknown Affiliation
Pennap, Grace Rinmecit I.
Unknown Affiliation
Potgieter, Natasha
Unknown Affiliation
Ramsaroop, Ugendri G.
South Africa, Johannesburg
University of the Witwatersrand
Sawadogo, Souleymane
Unknown Affiliation
Sabunya, T.
Unknown Affiliation
Trabelsi, Abdelhalim
Unknown Affiliation
Tswana, A. S.
Unknown Affiliation
Yeats, Jane
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 155
Authors: 20
Affiliations: 5
Identifiers
Doi:
10.1016/S0264-410X(02)00616-3
ISSN:
0264410X
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Multi-countries