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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Anti-ulcer activity of the 9alpha-bromo analogue of Beclomethasone dipropionate against ethanol-induced gastric mucosal injury in rats
Journal of Medicinal Plants Research, Volume 5, No. 4, Year 2011
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Description
The present study was performed to evaluate the anti-ulcer activity of the 9alpha-bromo analogue of Beclomethasone dipropionate against ethanol-induced gastric ulcer. Experimental groups were orally pre-treated with different doses of the 9alpha-bromo analogue of B. dipropionate in 10% Tween 20 solution. Ulcer control groups were pre-treated with vehicle solution and reference group was orally pre-treated with 20 mg/kg omeprazole. After one hour, all groups received absolute ethanol to generate gastric mucosal injury. After an additional hour, all rats were sacrificed and ulcer areas of gastric walls were determined. Grossly, ulcer control group exhibited severe mucosal injury, whereas pre-treatment with either omeprazole or the 9alpha-bromo analogue of B. dipropionate resulted in a significant decrease in acidity of gastric content, protection of gastric mucosal injury and increase in mucus production. Histological studies of gastric wall of ulcer control group revealed severe damage of gastric mucosa, along with edema and leucocyte infiltration of sub-mucosal layer compared to rats pre-treated with either omeprazole or 9alpha-bromo analogue of beclomethasone dipropionate. In conclusion, present finding suggests that the 9alpha-bromo analogue of B. dipropionate promotes ulcer protection as ascertained by the comparative decreases in ulcer areas, reduction of edema and leucocyte infiltration of the sub mucosal layer. ©2011 Academic Journals.
Authors & Co-Authors
Ketuly, Kamal Aziz
Malaysia, Kuala Lumpur
Universiti Malaya
Abdulla, Mahmood Ameen
Malaysia, Kuala Lumpur
Universiti Malaya
Hadi, Hamid A.
Malaysia, Kuala Lumpur
Universiti Malaya
Mariod, Abdalbasit Adam
Sudan, Khartoum
Sudan University of Science and Technology
Abdel Wahab, Siddig Ibrahim
Malaysia, Serdang
Universiti Putra Malaysia
Statistics
Citations: 5
Authors: 5
Affiliations: 3
Identifiers
ISSN:
19960875
e-ISSN:
19960875
Research Areas
Violence And Injury
Study Design
Randomised Control Trial