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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
First report of bla
NDM-1
-producing Acinetobacter baumannii isolated in Lebanon from civilians wounded during the Syrian war
International Journal of Infectious Diseases, Volume 21, Year 2014
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Description
Objectives: The emergence of carbapenem-resistant Acinetobacter baumannii has been observed worldwide. We describe the first detection of A. baumannii carrying the blaNDM-1 gene in Lebanon, isolated from Syrian patients wounded during the civil war. Methods: Four carbapenem-resistant A. baumannii strains isolated in 2012 in the Tripoli Government Hospital, Lebanon, from civilians wounded during the Syrian war, were analysed. Susceptibility was determined by disk diffusion testing, and resistance to carbapenems was confirmed by Etest. The presence of blaOXA-23-like, blaOXA-24-like, blaOXA-58-like, blaOXA-143-like, and blaNDM was investigated by PCR. Clonal relationships were studied by pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST), and blaOXA-51 sequence-based typing. Results: All isolates harboured the blaNDM-1 gene and were negative for other tested carbapenemases. They all belonged to the sequence type 85 and formed a single cluster by PFGE. Finally, blaOXA-51-like gene sequencing revealed the presence of the blaOXA-94 variant in all four isolates. Conclusion: These findings show that Syria constitutes a reservoir for NDM-1-producing bacteria. These results also highlight the need for effective measures to stop the threatening spread of such strains. © 2014 The Authors.
Authors & Co-Authors
Rafei, Rayane
France, Angers
Groupe D'étude Des Interactions Hôte Pathogène
Lebanon, Beirut
Université Libanaise
Dabboussi, Fouad
Lebanon, Beirut
Université Libanaise
Hamzé, Monzer M.
Lebanon, Beirut
Université Libanaise
Éveillard, Matthieu
France, Angers
Groupe D'étude Des Interactions Hôte Pathogène
France, Angers
Chu Angers
Lemarié, Carole
France, Angers
Chu Angers
Mallat, Hassan
Lebanon, Beirut
Université Libanaise
Rolain, Jean Marc
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Joly-Guillou, Marie Laure 1.
France, Angers
Groupe D'étude Des Interactions Hôte Pathogène
France, Angers
Chu Angers
Kempf, Marie Claude
France, Angers
Groupe D'étude Des Interactions Hôte Pathogène
France, Angers
Chu Angers
Statistics
Citations: 77
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1016/j.ijid.2014.01.004
ISSN:
12019712
e-ISSN:
18783511
Research Areas
Genetics And Genomics
Health System And Policy