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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Interleukin-6-related genotypes, body mass index, and risk of multiple myeloma and plasmacytoma
Cancer Epidemiology Biomarkers and Prevention, Volume 15, No. 11, Year 2006
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Description
Interleukin-6 (IL-6) promotes normal plasma cell development and proliferation of myeloma cells in culture. We evaluated IL-6 genotypes and body mass index (BMI) in a case-control study of multiple myeloma and plasmacytoma. DNA samples and questionnaires were obtained from incident cases of multiple myeloma (n = 134) and plasmacytoma (n = 16; plasma cell neoplasms) ascertained from the Los Angeles County population-based cancer registry and from siblings or cousins of cases (family controls, n = 112) and population controls (n = 126). Genotypes evaluated included IL-6 promoter gene single nucleotide polymorphisms (SNP) at positions -174, -572, and -597; one variable number of tandem repeats (-373 AnTn); and one SNP in the IL-6 receptor (IL-6rα) gene at position -358. The variant allele of the IL-6 promoter SNP -572 was associated with a roughly 2-fold increased risk of plasma cell neoplasms when cases were compared with family [odds ratio (OR), 1.8; 95% confidence interval (95% CI), 0.7-4.7] or population controls (OR, 2.4; 95% CI, 1.2-4.7). The -373 9A/9A genotype was associated with a decreased risk compared with the most common genotype (OR for cases versus family controls, 0.4; 95% CI, 0.1-1.7; OR for cases versus population controls, 0.3; 95% CI, 0.1-0.9). No other SNPs were associated with risk. Obesity (BMI ≥ 30 kg/m2) increased risk nonsignificantly by 40% and 80% when cases were compared with family controls or population controls, respectively, relative to persons with a BMI of <25 kg/m2. These results suggest that IL-6 promoter genotypes may be associated with increased risk of plasma cell neoplasms. Copyright © 2006 American Association for Cancer Research.
Authors & Co-Authors
Cozen, Wendy
United States, Los Angeles
University of Southern California
Gebregziabher, Mulugeta G.
United States, Charleston
Medical University of South Carolina
Conti, David V.
United States, Los Angeles
University of Southern California
van den Berg, David J.
United States, Los Angeles
University of Southern California
Coetzee, Gerhard A.
United States, Los Angeles
University of Southern California
Wang, Sophia S.
United States, Bethesda
National Institutes of Health Nih
Bernstein, Leslie R.
United States, Los Angeles
University of Southern California
Hartge, Patricia A.
United States, Bethesda
National Institutes of Health Nih
Coetzee, Simon G.
United States, Los Angeles
University of Southern California
Ingles, Sue Ann
United States, Los Angeles
University of Southern California
Statistics
Citations: 56
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1158/1055-9965.EPI-06-0446
ISSN:
10559965
Research Areas
Cancer
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Case-Control Study