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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Association between CYP2B6 polymorphisms and Nevirapine-induced SJS/TEN: A pharmacogenetics study
European Journal of Clinical Pharmacology, Volume 69, No. 11, Year 2013
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Description
Purpose: Nevirapine (NVP) is a non-nucleoside reverse transcriptase inhibitor, widely prescribed for type 1 human immunodeficiency virus infection. A small proportion of individuals treated with NVP experience severe cutaneous adverse events, including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Our aim was to verify whether genetic variability in NVP-metabolizing cytochromes or in transporter genes could be involved in susceptibility to SJS/TEN. Methods: Twenty-seven patients with NVP-induced SJS/TEN and 78 controls, all from Mozambique, were genotyped for the ABCB1 and ABCC10 transporter genes and for CYP2B6, CYP3A4 and CYP3A5 cytochrome gene variants. A case-control and a genotype-phenotype analysis were performed. Results: CYP2B6 G516T and T983C single nucleotide polymorphisms (SNPs) were found to be associated with SJS/TEN susceptibility. The 983C allele in particular was found to be highly associated with a higher risk to develop SJS/TEN [odds ratio (OR) 4.2, P = 0.0047]. The GT haplotype (wildtype for both SNPs) showed a protective effect, with an OR = 0.33 (P = 0.0016). Conclusions: This is the first study showing that genetic variability in a metabolizing enzyme can also contribute to NVP-induced SJS/TEN susceptibility. © 2013 Springer-Verlag Berlin Heidelberg.
Authors & Co-Authors
Ciccacci, Cinzia
Italy, Rome
Facoltà Di Medicina e Chirurgia Università Degli Studi Di Roma Tor Vergata
Di Fusco, Davide
Italy, Rome
Facoltà Di Medicina e Chirurgia Università Degli Studi Di Roma Tor Vergata
Zimba, Inês Da Vitoria M.
Mozambique, Maputo
Dream Program
Erba, Fulvio
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Novelli, Giuseppe
Italy, Rome
Facoltà Di Medicina e Chirurgia Università Degli Studi Di Roma Tor Vergata
Palombi, Leonardo
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Borgiani, Paola
Italy, Rome
Facoltà Di Medicina e Chirurgia Università Degli Studi Di Roma Tor Vergata
Liotta, Giuseppe
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Statistics
Citations: 9
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1007/s00228-013-1549-x
e-ISSN:
14321041
Research Areas
Environmental
Genetics And Genomics
Study Design
Case-Control Study
Study Locations
Mozambique