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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial
The Lancet, Volume 397, No. 10289, Year 2021
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Description
Background: Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19. Methods: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. Eligible and consenting patients were randomly assigned (1:1) to receive either usual care alone (usual care group) or usual care plus high-titre convalescent plasma (convalescent plasma group). The primary outcome was 28-day mortality, analysed on an intention-to-treat basis. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings: Between May 28, 2020, and Jan 15, 2021, 11558 (71%) of 16287 patients enrolled in RECOVERY were eligible to receive convalescent plasma and were assigned to either the convalescent plasma group or the usual care group. There was no significant difference in 28-day mortality between the two groups: 1399 (24%) of 5795 patients in the convalescent plasma group and 1408 (24%) of 5763 patients in the usual care group died within 28 days (rate ratio 1·00, 95% CI 0·93–1·07; p=0·95). The 28-day mortality rate ratio was similar in all prespecified subgroups of patients, including in those patients without detectable SARS-CoV-2 antibodies at randomisation. Allocation to convalescent plasma had no significant effect on the proportion of patients discharged from hospital within 28 days (3832 [66%] patients in the convalescent plasma group vs 3822 [66%] patients in the usual care group; rate ratio 0·99, 95% CI 0·94–1·03; p=0·57). Among those not on invasive mechanical ventilation at randomisation, there was no significant difference in the proportion of patients meeting the composite endpoint of progression to invasive mechanical ventilation or death (1568 [29%] of 5493 patients in the convalescent plasma group vs 1568 [29%] of 5448 patients in the usual care group; rate ratio 0·99, 95% CI 0·93–1·05; p=0·79). Interpretation: In patients hospitalised with COVID-19, high-titre convalescent plasma did not improve survival or other prespecified clinical outcomes. Funding: UK Research and Innovation (Medical Research Council) and National Institute of Health Research. © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Authors & Co-Authors
Abbas, Ali
Unknown Affiliation
Abbass, Hakam
Unknown Affiliation
Abdul-Kadir, Rezan
Unknown Affiliation
Adam, Matthew
Unknown Affiliation
Adams, Katherine
Unknown Affiliation
Ademokun, Debo
Unknown Affiliation
Agbeko, Rachel Sarah
Unknown Affiliation
Ahmad, Syed Masroor
Unknown Affiliation
Ahmed, Khalid E.
Unknown Affiliation
Ahmed, Muhammad S.
Unknown Affiliation
Ahmed, Osama Abdelhakim Aly
Unknown Affiliation
Akhtar, Nasim
Unknown Affiliation
Al-Abadi, Eslam
Unknown Affiliation
Alexander, Alison
Unknown Affiliation
Alexander, John H.P.
Unknown Affiliation
Alghazawi, Laith Omar Khalaf
Unknown Affiliation
Ali, Mohammad Rizwan
Unknown Affiliation
Ali, Syed Danish
Unknown Affiliation
Allen, Sam H.
Unknown Affiliation
Al-Shahi Salman, Rustam
Unknown Affiliation
Anderson, Laura N.
Unknown Affiliation
Ashraf, Muhammad Zubair
Unknown Affiliation
Atugonza, Rita
Unknown Affiliation
Aujayeb, Avinash
Unknown Affiliation
Babiker, Babiker Ahmed
Unknown Affiliation
Baillie, John Kenneth
Unknown Affiliation
Baird, Yolanda
Unknown Affiliation
Bakerly, Nawar Diar
Unknown Affiliation
Balasubramaniam, Madhu Shankar
Unknown Affiliation
Ball, Ceri
Unknown Affiliation
Bamford, A. R.J.
Unknown Affiliation
Bandi, Srini
Unknown Affiliation
Barber, Alexandra E.
Unknown Affiliation
Barlow, Gavin D.
Unknown Affiliation
Barnacle, James R.
Unknown Affiliation
Barnett-Vanes, Ashton
Unknown Affiliation
Barr, David Adam
Unknown Affiliation
Bassford, Christopher R.
Unknown Affiliation
Bayes, Hannah Kelly
Unknown Affiliation
Bazaz, Rohit
Unknown Affiliation
Bell, Louise V.
Unknown Affiliation
Bernatoniene, Jolanta
Unknown Affiliation
Berriman, Thomas
Unknown Affiliation
Beynon, Fenella
Unknown Affiliation
Bhagani, Sanjay R.
Unknown Affiliation
Bibi, Fatima
Unknown Affiliation
Bicanic, Tihana A.
Unknown Affiliation
Bikov, Andras
Unknown Affiliation
Bisnauthsing, Karen N.
Unknown Affiliation
Black, Mairead E.
Unknown Affiliation
Blazeby, Jane M.
Unknown Affiliation
Blencowe, Natalie S.
Unknown Affiliation
Boffito, Marta A.
Unknown Affiliation
Bokhandi, Sumit S.
Unknown Affiliation
Bousfield, Rachel
Unknown Affiliation
Bowman, Louise J.
Unknown Affiliation
Boyles, Louise
Unknown Affiliation
Brightling, Christopher Edward
Unknown Affiliation
Brown, Elizabeth R.
Unknown Affiliation
Brown, Louise Clare
Unknown Affiliation
Brown, Robert Clark
Unknown Affiliation
Brown, Steven Ross
Unknown Affiliation
Brown, Tom
Unknown Affiliation
Brunskill, N. J.
Unknown Affiliation
Buch, Maya Hema
Unknown Affiliation
Buchanan, Ruaridh
Unknown Affiliation
Buckland, Matthew S.
Unknown Affiliation
Burden, Christy A.
Unknown Affiliation
Burden, Tom G.
Unknown Affiliation
Burns, Karen E.A.
Unknown Affiliation
Calisti, Giorgio
Unknown Affiliation
Camm, Christian Fielder
Unknown Affiliation
Campbell, Jonathon R.
Unknown Affiliation
Camsooksai, Julie
Unknown Affiliation
Capp, Angelika
Unknown Affiliation
Carley, Simon David
Unknown Affiliation
Statistics
Citations: 309
Authors: 76
Identifiers
Doi:
10.1016/S0140-6736(21)00897-7
ISSN:
01406736
Research Areas
Covid
Health System And Policy
Study Design
Randomised Control Trial