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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
In vivo evidence for the resistance of Theileria annulata to buparvaquone
Veterinary Parasitology, Volume 169, No. 3-4, Year 2010
Notification
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Description
The present study describes an outbreak of tropical theileriosis cases refractory to buparvaquone treatment, which occurred in a small-size dairy farm in Tunisia. Out of seven treated cows, four died in spite of repeated buparvaquone injections (2.5 and 5mgkg-1) and the monitoring of the affected cows showed no improvement of the course of the disease with a consistent decrease in the haematocrit, the persistence of fever and an increased parasitaemia after treatment. Ticks were fed on a calf experimentally infected with one isolate established in culture from one of the cases and the resultant infected ticks ground up to generate a supernatant infected with the potentially resistant stock. This was used to experimentally infect three calves, and the clinical observations, post-buparvaquone treatment, showed an absence of the usual effect of buparvaquone treatment on the parasite Theileria annulata, such as the rapid decline of schizont index and parasitaemia and a rapid recovery from the disease. These results confirmed for the first time the occurrence of resistance to buparvaquone in the protozoan T. annulata. © 2010 Elsevier B.V.
Authors & Co-Authors
Mhadhbi, Moez
Tunisia, Sidi Thabet
Ecole Nationale de Médecine Vétérinaire
Naouach, Abdelkarim
Unknown Affiliation
Boumiza, Aïssa
Unknown Affiliation
Chaabani, Mohamed Faouzi
Unknown Affiliation
BenAbderazzak, Souha
Tunisia, Tunis
Institut Pasteur de Tunis
Darghouth, Mohamed Aziz
Tunisia, Sidi Thabet
Ecole Nationale de Médecine Vétérinaire
Statistics
Citations: 88
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.vetpar.2010.01.013
ISSN:
03044017
Study Locations
Tunisia