Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Impact of tuberculosis on mortality among HIV-infected patients receiving antiretroviral therapy in Uganda: A prospective cohort analysis
AIDS Research and Therapy, Volume 10, No. 1, Article 19, Year 2013
Notification
URL copied to clipboard!
Description
Background: Tuberculosis (TB) disease affects survival among HIV co-infected patients on antiretroviral therapy (ART). Yet, the magnitude of TB disease on mortality is poorly understood.Methods: Using a prospective cohort of 22,477 adult patients who initiated ART between August 2000 and June 2009 in Uganda, we assessed the effect of active pulmonary TB disease at the initiation of ART on all-cause mortality using a Cox proportional hazards model. Propensity score (PS) matching was used to control for potential confounding. Stratification and covariate adjustment for PS and not PS-based multivariable Cox models were also performed.Results: A total of 1,609 (7.52%) patients had active pulmonary TB at the start of ART. TB patients had higher proportions of being male, suffering from AIDS-defining illnesses, having World Health Organization (WHO) disease stage III or IV, and having lower CD4 cell counts at baseline (p < 0.001). The percentages of death during follow-up were 10.47% and 6.38% for patients with and without TB, respectively. The hazard ratio (HR) for mortality comparing TB to non-TB patients using 1,686 PS-matched pairs was 1.37 (95% confidence interval [CI]: 1.08 - 1.75), less marked than the crude estimate (HR = 1.74, 95% CI: 1.49 - 2.04). The other PS-based methods and not PS-based multivariable Cox model produced similar results.Conclusions: After controlling for important confounding variables, HIV patients who had TB at the initiation of ART in Uganda had an approximate 37% increased hazard of overall mortality relative to non-TB patients. © 2013 Chu et al.; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3716897/bin/1742-6405-10-19-S1.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3716897/bin/1742-6405-10-19-S2.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3716897/bin/1742-6405-10-19-S3.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3716897/bin/1742-6405-10-19-S4.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3716897/bin/1742-6405-10-19-S5.tiff
https://efashare.b-cdn.net/share/pmc/articles/PMC3716897/bin/1742-6405-10-19-S6.tiff
Authors & Co-Authors
Chu, Rong
Canada, Hamilton
Mcmaster University
Canada, London
St. Joseph's Health Care London
Mills, Edward J.
Canada, Hamilton
Mcmaster University
Canada, Ottawa
University of Ottawa
Beyene, Joseph
Canada, Hamilton
Mcmaster University
Pullenayegum, Eleanor M.
Canada, Hamilton
Mcmaster University
Canada, London
St. Joseph's Health Care London
Bakanda, Celestin
Uganda, Kampala
Aids Support Organization Uganda
Nachega, J. B.
South Africa, Stellenbosch
Stellenbosch University
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Devereaux, Philip James
Canada, Hamilton
Mcmaster University
Canada, Hamilton
Hamilton Health Sciences
Thabane, Lehana
Canada, Hamilton
Mcmaster University
Canada, London
St. Joseph's Health Care London
Statistics
Citations: 18
Authors: 8
Affiliations: 7
Identifiers
Doi:
10.1186/1742-6405-10-19
e-ISSN:
17426405
Research Areas
Environmental
Infectious Diseases
Study Design
Cohort Study
Case-Control Study
Study Locations
Uganda
Participants Gender
Male