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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Association of -592C/A, -819C/T and -1082A/G interleukin-10 promoter polymorphisms with idiopathic recurrent spontaneous abortion
Molecular Human Reproduction, Volume 12, No. 12, Year 2006
Notification
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Description
Increasing evidence supports a role for altered T helper 1 (Th1)-Th2 cytokine balance in idiopathic recurrent spontaneous abortion (RSA). The aim of this study was to investigate the association of the interleukin 10 (IL-10) promoter polymorphisms -592C/A, -819C/T and -1082A/G with RSA. Women (n = 350) with at least three consecutive spontaneous abortions (RSA cases) and 200 control women with at least two successful pregnancies were included. The frequency of the -819T allele [P = 0.05, odds ratio (OR) = 1.51], but not other single-nucleotide polymorphisms (SNPs), was higher among RSA patients. Complete linkage disequilibrium (LD) was seen between -592C and -819C and -1082G alleles, as well as between -592A and -819T and between -819C and -1082G alleles only among patients. Although the genotype frequencies (except for -819C/C) of the three polymorphisms were comparable between patients and controls, higher frequency of -592A/-819T/-1082A haplotype (OR = 4.01, 95% CI = 1.83-7.95) was seen in cases versus controls. Regression analysis indicated that, after adjusting for potential variables, -592C/A (OR = 3.32, 95% CI = 1.76-6.27) and -819C/T (OR = 5.06, 95% CI = 2.59-9.91) were associated with exclusively early but not exclusively late RSA, where negative association for both was noted. This supports the notion of involvement of IL-10 -592C/A and -819C/T polymorphisms as inherited risk factors of idiopathic RSA. © 2006 Oxford University Press.
Authors & Co-Authors
Zammiti, Walid
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Mtiraoui, Nabil
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Cochery-Nouvellon, E.
France, Montpellier
Université de Montpellier
Mahjoub, Touhami
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Almawi, Wassim Y.
Bahrain, Manama
Arabian Gulf University
Gris, Jean Christophe R.
France, Montpellier
Université de Montpellier
Statistics
Citations: 50
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1093/molehr/gal084
ISSN:
13609947
e-ISSN:
14602407
Research Areas
Genetics And Genomics
Sexual And Reproductive Health
Study Design
Case-Control Study
Study Approach
Quantitative
Participants Gender
Female