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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Availability and use of rapid diagnostic tests for the management of acute childhood infections in Europe: A cross-sectional survey of paediatricians
PLoS ONE, Volume 17, No. 12 December, Article e0275336, Year 2022
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Description
Background Point-of-care-tests (POCTs) have been advocated to optimise care in patients with infections but their actual use varies. This study aimed to estimate the variability in the adoption of current POCTs by paediatricians across Europe, and to explore the determinants of variability. Methods and findings A cross-sectional survey was conducted of hospital and primary care paediatricians, recruited through professional networks. Questions focused on the availability and use of currently available POCTs. Data were analysed descriptively and using Median Odds Ratio (MOR) to measure variation between countries. Multilevel regression modelling using changes in the area under the receiver operating characteristic curve of models were used to assess the contribution of individual or workplace versus country level factors, to the observed variation. The commonest POCT was urine dipsticks (UD) which were available to >80% of primary care and hospital paediatricians in 68% (13/19) and 79% (23/29) countries, respectively. Availability of all POCTs varied between countries. In primary care, the country (MOR) varied from 1.61 (95%CI: 1.04-2.58) for lactate to 7.28 (95%CI: 3.04-24.35) for UD. In hospitals, the country MOR varied from 1.37 (95%CI:1.04-1.80) for lactate to 11.93 (95% CI:3.35-72.23) for UD. Most paediatricians in primary care (69%, 795/1154) and hospital (81%, 962/1188) would use a diagnostic test in the case scenario of an infant with undifferentiated fever. Multilevel regression modelling showed that the country of work was more important in predicting both the availability and use of POCTs than individual or workplace characteristics. Conclusion There is substantial variability in the adoption of POCTs for the management of acute infections in children across Europe. To inform future implementation of both existing and innovative tests, further research is needed to understand what drives the variation between countries, the needs of frontline clinicians, and the role of diagnostic tests in the management of acute childhood infections. © 2022 Dewez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Authors & Co-Authors
Dewez, Juan Emmanuel
United Kingdom, London
London School of Hygiene & Tropical Medicine
Belgium, Brussels
European Union
Pembrey, Lucy Jane
United Kingdom, London
London School of Hygiene & Tropical Medicine
Nijman, Ruud Gerard
Belgium, Brussels
European Union
United Kingdom, London
Imperial College London
Hadjipanayis, Adamos A.
Cyprus, Larnaca
Larnaca General Hospital
Cyprus, Nicosia
European University Cyprus
Lim, Emma J.
Belgium, Brussels
European Union
United Kingdom, Newcastle
The Newcastle Upon Tyne Hospitals Nhs Foundation Trust
United Kingdom, Newcastle
Newcastle University
Emonts, Marieke
Belgium, Brussels
European Union
United Kingdom, Newcastle
The Newcastle Upon Tyne Hospitals Nhs Foundation Trust
United Kingdom, Newcastle
Newcastle University
Kohlfuerst, Daniela S.
Belgium, Brussels
European Union
Austria, Graz
Medizinische Universität Graz
Brengel-Pesce, Karen
Belgium, Brussels
European Union
Mallet, François
Belgium, Brussels
European Union
von Both, Ulrich
Belgium, Brussels
European Union
Germany, Munich
Ludwig-maximilians-universität München
Tsolia, Maria N.
Belgium, Brussels
European Union
Eleftheriou, Irini
Belgium, Brussels
European Union
Zavadska, Dace
Belgium, Brussels
European Union
Latvia, Riga
Bērnu Klīniskā Universitātes Slimnīca
de Groot, Ronald C.A.
Belgium, Brussels
European Union
Netherlands, Nijmegen
Radboud University Medical Center
van der Flier, Michiel
Belgium, Brussels
European Union
Netherlands, Utrecht
University Medical Center Utrecht
Moll, Henriëtte A.
Belgium, Brussels
European Union
Netherlands, Rotterdam
Erasmus Mc
Hagedoorn, Nienke N.
Belgium, Brussels
European Union
Netherlands, Rotterdam
Erasmus Mc
Oostenbrink, Rianne
Netherlands, Rotterdam
Erasmus Mc
Kuijpers, Taco W.
Belgium, Brussels
European Union
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Pokorn, Marko
Belgium, Brussels
European Union
Slovenia, Ljubljana
Univerzitetni Klinični Center Ljubljana
Vincek, Katarina
Belgium, Brussels
European Union
Slovenia, Ljubljana
Univerzitetni Klinični Center Ljubljana
Agyeman, Philipp Kwame Abayie
Belgium, Brussels
European Union
Switzerland, Bern
University of Bern
Carrol, Enitan D.
Belgium, Brussels
European Union
United Kingdom, Liverpool
Alder Hey Children's Hospital
Paulus, Stéphane C.
Belgium, Brussels
European Union
United Kingdom, Oxford
University of Oxford
Cunnington, Aubrey J.
Belgium, Brussels
European Union
United Kingdom, London
Imperial College London
Herberg, Jethro Adam
Belgium, Brussels
European Union
United Kingdom, London
Imperial College London
Levin, Michael L.
Belgium, Brussels
European Union
United Kingdom, London
Imperial College London
da Dalt, L.
Italy, Padua
Azienda Ospedale Università Padova
Valiulis, Arũnas
Lithuania, Vilnius
Vilniaus Universitetas
Lapatto, Risto
Finland, Helsinki
Helsinki University Hospital
Syridou, Garyfallia
Unknown Affiliation
Torpiano, Paul
Malta, Valletta
Mater Dei Hospital
Størdal, Ketil
Norway, Oslo
Universitetet I Oslo
Wyder, Corinne
Unknown Affiliation
Romankevych, Ivanna V.
Unknown Affiliation
Ibáñez-Micó, Salvador
Spain, Murcia
Hospital Clínico Universitario Virgen de la Arrixaca
Yeung, Shunmay M.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Belgium, Brussels
European Union
United Kingdom, London
Imperial College London
Statistics
Citations: 4
Authors: 37
Affiliations: 30
Identifiers
Doi:
10.1371/journal.pone.0275336
ISSN:
19326203
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study
Case-Control Study
Study Approach
Quantitative