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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Waves of retrotransposon expansion remodel genome organization and CTCF binding in multiple mammalian lineages
Cell, Volume 148, No. 1-2, Year 2012
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Description
CTCF-binding locations represent regulatory sequences that are highly constrained over the course of evolution. To gain insight into how these DNA elements are conserved and spread through the genome, we defined the full spectrum of CTCF-binding sites, including a 33/34-mer motif, and identified over five thousand highly conserved, robust, and tissue-independent CTCF-binding locations by comparing ChIP-seq data from six mammals. Our data indicate that activation of retroelements has produced species-specific expansions of CTCF binding in rodents, dogs, and opossum, which often functionally serve as chromatin and transcriptional insulators. We discovered fossilized repeat elements flanking deeply conserved CTCF-binding regions, indicating that similar retrotransposon expansions occurred hundreds of millions of years ago. Repeat-driven dispersal of CTCF binding is a fundamental, ancient, and still highly active mechanism of genome evolution in mammalian lineages. PaperClip: © 2012 Elsevier Inc.
Authors & Co-Authors
Brown, Gordon D.A.
United Kingdom, London
Cancer Research uk
Marshall, Aileen E.
United Kingdom, London
Cancer Research uk
United Kingdom, Cambridge
Addenbrooke's Hospital
Flicek, Paul R.
United Kingdom, Hinxton
Embl’s European Bioinformatics Institute
United Kingdom, Hinxton
Wellcome Sanger Institute
Statistics
Citations: 405
Authors: 3
Affiliations: 4
Identifiers
Doi:
10.1016/j.cell.2011.11.058
ISSN:
00928674
Research Areas
Genetics And Genomics