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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Patterns of diversity in HIV-related loci among subspecies of chimpanzee: Concordance at CCR5 and differences at CXCR4 and CX
3
CR1
Molecular Biology and Evolution, Volume 26, No. 4, Year 2009
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Description
Human immunodeficiency virus type 1 (HIV-1) arose in humans via zoonotic transmissions of simian immunodeficiency viruses (SIVcpz) from common chimpanzees, Pan troglodytes. Despite the close relatedness of the two viruses and their hosts, we do not yet understand what causes SIVcpz to be nonpathogenic in chimpanzees, and HIV/AIDS to be one of the most devastating infectious diseases to have emerged in humans. There have been a number of genes identified in humans that confer disease resistance/susceptibility toward HIV-1, but little is known about the evolution and diversity of most of these chemokine receptor genes in chimpanzees. Here we show that genetic variation in chimpanzees differs across the various loci related to HIV-1, and that the pattern of variation differs among the chimpanzee subspecies. For all three subspecies, low diversity at CCR5 is confined to a small area of chromosome 3, suggesting that a selective sweep at this locus may have predated subspeciation. In contrast, diversity and neutrality tests suggest differing evolutionary forces among subspecies at CXCR4 and CX3CR1, with directional selection (in Pan troglodytes vellerosus) and demographic expansion (Pan troglodytes troglodytes) offering the most likely scenarios. These are some of the first data demonstrating differentiation in functional loci among chimpanzee subspecies. © The Author 2009. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved.
Authors & Co-Authors
MacFie, T. S.
United Kingdom, Cambridge
University of Cambridge
Nerrienet, Eric
Cameroon, Yaounde
Centre Pasteur du Cameroun
De Groot, N. G.
Netherlands, Rijswijk
Biomedical Primate Research Centre - Rijswijk
Bontrop, Ronald E.
Netherlands, Rijswijk
Biomedical Primate Research Centre - Rijswijk
Mundy, Nicholas I.
United Kingdom, Cambridge
University of Cambridge
Statistics
Citations: 18
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1093/molbev/msp016
ISSN:
07374038
e-ISSN:
15371719
Research Areas
Genetics And Genomics
Infectious Diseases