Apolar Annonaceous acetogenins from the fruit pulp of Annona muricata

A methylene chloride extract of the pulp of Annona muricata L. was fractionated in search for scarcely functionalized Annonaceous acetogenins (type E). Previously known C-35 and C-37 mono-epoxy unsaturated compounds, epomuricenins-A and-B (1+2) and epomusenins-A and-B (3+4), were obtained. Two new mono-epoxy saturated C-35 representatives, epomurinins-A and-B (5+6) were also isolated.