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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Synthesis, characterization and antibacterial activity of new fluorescent chitosan derivatives
International Journal of Biological Macromolecules, Volume 65, Year 2014
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Description
The present work aims to the development of innovative new derivatives of chitosan that can be used for medical applications. This innovation is based on the synthesis and characterization of chitosan-g-aminoanthracene derivatives. Thus, N-(anthracen-9-yl)-4,6-dichloro-[1,3,5]-triazin-2-amine (AT) reacted with chitosan by the following steps: at first, cyanuric chloride reacted with 9-aminoanthracene to obtain N-(anthracen-9-yl)-4,6-dichloro-[1,3,5]-triazin-2-amine (AT), then the AT reacted with chitosan to obtain (CH-g-AT). The final product of CH-g-AT was separated, purified and re-crystallized by dioxane. The structure of the prepared chitosan derivatives was confirmed by FTIR-ATR, solid-NMR, TGA, X-RD, and DSC. The new chitosan derivatives showed fluorescence spectra in liquid and in solid state as well. CH-g-AT showed also high antibacterial activity against gram -ve species (Escherichia coli). © 2014 Elsevier B.V.
Authors & Co-Authors
Přichystalová, Hana
Czech Republic, Pardubice
Univerzita Pardubice
Almonasy, Numan
Czech Republic, Pardubice
Univerzita Pardubice
Abdel-Mohsen, A. M.
Czech Republic, Brno
Brno University of Technology
Egypt, Giza
National Research Centre
Abdel-Rahman, Rasha M.
Czech Republic, Pardubice
Univerzita Pardubice
Fouda, Moustafa M.G.
Saudi Arabia, Riyadh
College of Sciences
Egypt, Giza
National Research Centre
Vojtová, Lucy
Czech Republic, Brno
Brno University of Technology
Kobera, Libor
Czech Republic, Prague
Institute of Macromolecular Chemistry of the Academy of Sciences of the Czech Republic
Spotz, Zdeněk
Czech Republic, Brno
Brno University of Technology
Burgert, Ladislav
Czech Republic, Pardubice
Univerzita Pardubice
Jánčář, Joseph
Czech Republic, Brno
Brno University of Technology
Czech Republic, Brno
Brno University of Technology, Faculty of Chemistry
Statistics
Citations: 45
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1016/j.ijbiomac.2014.01.050
e-ISSN:
18790003