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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Characterization of HIV type 1 genetic diversity among South African participants enrolled in the AIDS Vaccine Integrated Project (AVIP) Study
AIDS Research and Human Retroviruses, Volume 26, No. 6, Year 2010
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Description
The genetic diversity of HIV-1 strains circulating among HIV-1-infected South Africans was investigated in a cohort of 420 individuals enrolled as part of the AIDS Vaccine Integrated Project (AVIP) study. Representative samples (10%) were randomly selected from treatment-naive participants. Viral RNA was extracted for reverse transcriptase-initiated amplification and population-based sequencing of partial pol (encompassing protease and reverse transcriptase) and full-length integrase. Overall, HIV-1 sequences confirmed that 97.1% and 96.9% were HIV-1 subtype C in pol and integrase, respectively. Two participants were infected with unique A1/C and C/A1 recombinants in pol/integrase. Further pol sequence analysis identified mutation patterns associated with high level resistance to NNRTIs in two participants, whereas no primary mutations conferring resistance to integrase inhibitors were detected. The predominance of HIV-1 subtype C in South African populations is therefore confirmed in the AVIP cohort finalized for testing preventive or therapeutic vaccines against HIV-1 infection. © 2010, Mary Ann Liebert, Inc.
Authors & Co-Authors
Papathanasopoulos, Maria
South Africa, Johannesburg
School of Clinical Medicine
Vardas, Eftyhia
South Africa, Johannesburg
School of Clinical Medicine
Wallis, Carole Lorraine
South Africa, Johannesburg
School of Clinical Medicine
Glashoff, Richard Helmuth
South Africa, Stellenbosch
Stellenbosch University
Buttò, Stefano
Italy, Rome
Istituto Superiore Di Sanita
Poli, Guido
Italy, Milan
Irccs Ospedale San Raffaele
Italy, Milan
Università Vita-salute San Raffaele
Malnati, Mauro S.
Italy, Milan
Irccs Ospedale San Raffaele
Clerici, Mario S.
Italy, Milan
Università Degli Studi Di Milano
Ensoli, Barbara
Italy, Rome
Istituto Superiore Di Sanita
Statistics
Citations: 14
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1089/aid.2009.0281
ISSN:
08892229
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study