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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Gene-expression profiling discriminates between cerebral malaria (CM)-susceptible mice and CM-resistant mice
Journal of Infectious Diseases, Volume 193, No. 2, Year 2006
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Description
The development of cerebral malaria (CM) in mice with Plasmodium berghei ANKA infection is under genetic control. Brain gene-expression patterns were investigated in well-defined genetically CM-resistant (CM-R; BALB/c and DBA/2) and CM-susceptible (CM-S; C57BL/6 and CBA/J) mice by use of cDNA microarrays. By combining transcriptional profiling with rigorous statistical methods and cluster analysis, we identified a set of 69 genes that perfectly discriminated between mouse strains and between CM-R and CM-S mice. The analysis of gene ontological terms revealed that the genes that clustered and were related to susceptibility to CM preferentially belonged to some biological process classes, such as those pertaining to immune responses. Using a false discovery rate of 5% and the Welch t test, we identified 31 genes with consistent differential expression between CM-R and CM-S mice. These data indicate that microarray analysis may be useful for identification of candidate genes that are potentially responsible for resistance or susceptibility to mouse CM and suggest that candidate genes identified in mice could be specifically tested in humans for an association with disease severity. © 2005 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Delahaye, Nicolas Frédéric
France, Marseille
Aix Marseille Université
Coltel, Nicolas
France, Paris
Cnrs Centre National de la Recherche Scientifique
Puthier, Denis
France, Paris
Inserm
Flori, Laurence
France, Marseille
Aix Marseille Université
France, Jouy-en-josas
Centre de Recherche Inrae Île-de-france - Jouy-en-josas - Antony
Houlgatte, Rémi
France, Paris
Inserm
Iraqi, Fuad A.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Nguyen, Catherine
France, Paris
Inserm
Grau, Georges Emile Raymond
France, Paris
Cnrs Centre National de la Recherche Scientifique
Rihet, Pascal
France, Marseille
Aix Marseille Université
France, Paris
Inserm
Statistics
Citations: 63
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1086/498579
ISSN:
00221899
Research Areas
Genetics And Genomics
Infectious Diseases