Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Malignant fibrous histiocytoma in childhood
Cancer, Volume 71, No. 12, Year 1993
Notification
URL copied to clipboard!
Description
Background. Malignant fibrous histiocytoma (MFH) is a neoplasm of late adult life and often is reported in the pediatric population. It is thought to behave more benignly in children than in adults. Method. Clinical and pathologic features, treatment, and outcome of nine pediatric patients seen at British Columbia's Children's Hospital between 1983 and 1990 were examined. The literature regarding pediatric malignant fibrous histiocytoma was reviewed. Results. The tumors included one primary renal tumor and two occurring in the orbit after radiation therapy for retinoblastoma during the neonatal period. Histologic examination showed that six tumors had a stori‐form‐pleomorphic pattern, one was myxoid, and two were angiomatoid in type. Six children are alive with a disease‐free survival of 20 months to 8 years after surgical resection. Two of these received adjuvant chemotherapy, none had radiation therapy. Three patients have died of disease, two with pulmonary metastases that developed despite multiagent chemotherapy and radiation therapy. Poor outcome was associated with large tumors, deep and proximal location, and the storiform‐pleomorphic histologic type with atypical mitoses. Conclusion. Malignant fibrous histiocytoma is similar in children and adults. Surgery is the mainstay of therapy, but the risk of local recurrence and pulmonary metastases indicates the need for adjuvant therapy in selected patients. Copyright © 1993 American Cancer Society
Authors & Co-Authors
Cole, C. H.
Canada, Vancouver
Bc Children's Hospital
Magee, J. F.
Canada, Vancouver
Bc Children's Hospital
Gianoulis, M.
Australia, Perth
Princess Margaret Hospital for Children
Rogers, P.
South Africa, Cape Town
Red Cross War Memorial Children's Hospital
Statistics
Citations: 46
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1002/1097-0142(19930615)71:12<4077::AID-CNCR2820711245>3.0.CO;2-6
ISSN:
0008543X
e-ISSN:
10970142
Research Areas
Cancer
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study