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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Acquisition and decay of antibodies to pregnancy-associated variant antigens on the surface of Plasmodium falciparum-infected erythrocytes that protect against placental parasitemia
Journal of Infectious Diseases, Volume 184, No. 5, Year 2001
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Description
Otherwise clinically immune women in areas endemic for malaria are highly susceptible to Plasmodium falciparum malaria during their first pregnancy. Pregnancy-associated malaria (PAM) is characterized by placental accumulation of infected erythrocytes that adhere to chondroitin sulfate A (CSA). Susceptibility to PAM decreases with increasing parity, apparently due to acquisition of antibodies directed against the variant surface antigens (VSAs) that mediate the adhesion to CSA (VSACSA). This study found that levels of VSACSA-specific antibodies depend on endemicity, that anti-VSACSA IgG is acquired during gestation week 20, and that plasma levels of the antibodies decline during the postpartum period. There is evidence that VSACSA-specific antibodies are linked to placental infection and that high antibody levels contribute to the control of placental infection by inhibiting parasite adhesion to CSA. Data suggest that VSACSA is a target for vaccination against PAM. ©2001 by the Infectious Diseases Society of America.
Authors & Co-Authors
Staalsøe, Trine
Denmark, Copenhagen
Rigshospitalet
Megnekou, Rosette
India, Ahmednagar
Biotechnology Centre
Fievét, Nadine
Cameroon, Yaounde
Organisation de Coordination Pour la Lutte Contre Les Endémies en Afrique Centrale
Ricke, Christina Hoeier
Denmark, Copenhagen
Rigshospitalet
Zornig, Hanne D.
Denmark, Copenhagen
Rigshospitalet
Leke, Rose G.F.
Cameroon, Yaounde
Université de Yaoundé I
Taylor, Diane Wallace
United States, Washington, D.c.
Georgetown University
Deloron, Philippe
France, Paris
Inserm
Hviid, Lars
Denmark, Copenhagen
Rigshospitalet
Statistics
Citations: 174
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1086/322809
ISSN:
00221899
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Participants Gender
Female