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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Meningococcal carriage, meningococcal disease and vaccination
Journal of Infection, Volume 16, No. 1, Year 1988
Notification
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Description
Group A meningococcal carriage rates were determined 6 months before and 6 and 18 months after a mass vaccination campaign with a combined group A and group C meningococcal polysaccharide vaccine in a rural area of The Gambia. During the first pre-vaccination survey, performed during an outbreak of meningococcal disease, the carriage rate was high (16 %). The carriage rate remained high during a second survey made 6 months after a vaccination campaign that covered approximately 90 % of the study population. A year later very few group A meningococcal carriers were found. Membrane protein patterns of isolates obtained before and after vaccination were similar. We conclude that vaccination had little influence on the carriage rate of group A meningococci but that this was influenced by changes in herd immunity or by other unidentified factors. © 1988 The British Society for the Study of Infection.
Authors & Co-Authors
Hassan-King, Musa K.A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Wall, Robert A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Greenwood, Brian M.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Statistics
Citations: 110
Authors: 3
Affiliations: 1
Identifiers
Doi:
10.1016/S0163-4453(88)96117-8
ISSN:
01634453
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Gambia