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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Cryptococcal Meningitis in Senegal: Epidemiology, Laboratory Findings, Therapeutic and Outcome of Cases Diagnosed from 2004 to 2011
Mycopathologia, Volume 176, No. 5-6, Year 2013
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Description
Background: Cryptococcal meningitis is one of the most important opportunistic infection and a major contributor to early mortality. In sub-Saharan Africa, particularly in Senegal, prevalence of cryptococcal meningitis remains high. This study aimed to describe the epidemiology, laboratory profile, therapeutic and outcome of cases diagnosed in Dakar. Methods: We analyzed the cryptococcosis cases diagnosed at the department of parasitology-mycology in Fann Teaching Hospital in Dakar from 2004 to 2011. The diagnosis was confirmed by culture on Sabouraud's dextrose agar and/or by India ink preparation and/or by cryptococcal antigen detection. The diagnosis methods were assessed by using culture as reference. Results: A total of 106 cases of cryptococcal meningitis were diagnosed. The prevalence of cryptococcal meningitis was 7.8 %. The mean age of the patients was 40.17 ± 9.89 years. There were slightly more male (53.8 %) than female (46.2 %) patients; 89.6 % were found to be infected with HIV, and the median CD4+ count was 27/mm3. Approximately 79.5 % of the patients had <100 CD4+ lymphocytes/mm3. India ink staining presented sensitivity at 94.11 % and specificity at 100 %. Sensitivity and specificity of cryptococcal antigen detection in cerebrospinal fluid were, respectively, 96.96 and 15.78 %. The most frequently used antifungal drug was fluconazole (86.7 %), and the mortality rate was 62.2 % (66 deaths). Conclusion: Early diagnosis is essential to control cryptococcosis, and countries should prioritize widespread and reliable access to rapid diagnostic cryptococcus antigen assays. But it is important to make available conventional methods (India ink and culture) in the maximum of laboratory in regional health facilities. © 2013 Springer Science+Business Media Dordrecht.
Authors & Co-Authors
Sow, Doudou Diagne
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Tine, Roger C.K.
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Sylla, Khadime
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Djiba, Mansata
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Ndour, Cheikh Tidiane
Senegal, Dakar
Fann Teaching Hospital
Dieng, Thérèse H.
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Ndiaye, Jean Louis Abdourahim
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Faye, Babacar Félix
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Ndiaye, Daouda F.
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Gaye, Oumar H.
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Dièng, Yémou D.
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Statistics
Citations: 21
Authors: 11
Affiliations: 2
Identifiers
Doi:
10.1007/s11046-013-9710-8
ISSN:
0301486X
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Senegal
Participants Gender
Male
Female