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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Potential genotoxicity of plant extracts used in Ethiopian traditional medicine
Journal of Ethnopharmacology, Volume 122, No. 1, Year 2009
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Description
Aim of the study: Although traditional herbal medicines are widely used in Ethiopia, no information is available on their potential genotoxicity. In the present study, hydroalcoholic extracts of Glinus lotoides, Plumbago zeylanica, Rumex steudelii and Thymus schimperi were evaluated for their DNA damaging effects using the comet assay. Material and methods: Mouse lymphoma L5178Y cells were exposed to different concentrations of the extracts for 3 h with and without metabolic activation (S9-mix) using 4-nitroquinoline-N-oxide and benzo(a)pyrene as positive controls, and vehicles as negative controls. Results: In the absence of S9, all extracts were found to induce significant DNA damage without affecting the cell viability. T. schimperi and R. steudelii were the most potent DNA-damaging extracts, and G. lotoides and P. zeylanica the least potent. The addition of S9 had different effects on the DNA damage induced by the extracts: it lowered the DNA damaging effect of P. zeylanica, did not affect the DNA damaging effect of T. schimperi, and increased the DNA damaging effects of R. steudelii and G. lotoides. Conclusion: The findings of the present study suggest that all extracts evaluated have a genotoxic potential in vitro which needs to be substantiated by further studies. © 2008 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Demma, Jemal
Sweden, Uppsala
Uppsala Universitet
Ethiopia, Addis Ababa
Addis Ababa University
Engidawork, Ephrem
Ethiopia, Addis Ababa
Addis Ababa University
Hellman, Björn E.
Sweden, Uppsala
Uppsala Universitet
Statistics
Citations: 86
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1016/j.jep.2008.12.013
ISSN:
03788741
Research Areas
Genetics And Genomics
Health System And Policy
Noncommunicable Diseases
Study Locations
Ethiopia