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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Plasmodium falciparum-infected erythrocytes induce tissue factor expression in endothelial cells and support the assembly of multimolecular coagulation complexes
Journal of Thrombosis and Haemostasis, Volume 5, No. 1, Year 2007
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Description
Background: Plasmodium falciparum malaria infects 300-500 million people every year, causing 1-2 million deaths annually. Evidence of a coagulation disorder, activation of endothelial cells (EC) and increase in inflammatory cytokines are often present in malaria. Objectives: We have asked whether interaction of parasitized red blood cells (pRBC) with EC induces tissue factor (TF) expression in vitro and in vivo. The role of phosphatidylserine-containing pRBC to support the assembly of blood coagulation complexes was also investigated. Results:We demonstrate that mature forms of pRBC induce functional expression of TF by EC in vitro with productive assembly of the extrinsic Xnase complex and initiation of the coagulation cascade. Late-stage pRBC also support the prothrombinase and intrinsic Xnase complex formation in vitro, and may function as activated platelets in the amplification phase of the blood coagulation. Notably, post-mortem brain sections obtained from P. falciparum-infected children who died from cerebral malaria and other causes display a consistent staining for TF in the EC. Conclusions: These findings place TF expression by endothelium and the amplification of the coagulation cascade by pRBC and/or activated platelets as potentially critical steps in the pathogenesis of malaria. Furthermore, it may allow investigators to test other therapeutic alternatives targeting TF or modulators of EC function in the treatment of malaria and/or its complications. © 2007 International Society on Thrombosis and Haemostasis.
Authors & Co-Authors
Francischetti, Ivo M.B.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Seydel, Karl B.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Monteiro, Robson Q.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Brazil, Rio de Janeiro
Universidade Federal do Rio de Janeiro
Whitten, Richard O.
United States, Olympia
Cellnetix Pathology
Erexson, C. R.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Noronha, A. L.L.
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Ostera, Graciela R.
Malawi
Niaid/nih
Kamiza, Steve B.
Unknown Affiliation
Molyneux, Malcolm Edward
Malawi, Zomba
University of Malawi
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Ward, Jerrold Michael
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Taylor, Terrie Ellen
United States, East Lansing
Msu College of Osteopathic Medicine
Statistics
Citations: 106
Authors: 11
Affiliations: 8
Identifiers
Doi:
10.1111/j.1538-7836.2006.02232.x
ISSN:
15387933
e-ISSN:
15387836
Research Areas
Infectious Diseases
Maternal And Child Health