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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Effects of malnutrition on children's immunity to bacterial antigens in northern Senegal
American Journal of Tropical Medicine and Hygiene, Volume 90, No. 3, Year 2014
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Description
To evaluate immunity to vaccine-preventable diseases according to nutritional status, a longitudinal study was conducted in Senegalese children ages 1-9 years old. A linear regression analysis predicted that weight for age was positively associated with immunoglobulin G (IgG) response to tetanus toxoid in children born during the rainy season or at the beginning of the dry season. A relationship between village, time of visits, and levels of antibodies to tetanus showed that environmental factors played a role in modulating humoral immunity to tetanus vaccine over time.Moreover, a whole-blood stimulation assay highlighted that the production of interferon-γ (IFN-γ) in response to tetanus toxoid was compromised in stunted children. However, the absence of cytokine modulation in response to Mycobacterium tuberculosis-purified protein derivatives and phytohemagglutinin suggests that the overall ability to produce IFN-γ was preserved in stunted children. Therefore, these results show that nutritional status can specifically alter the efficacy of long-lasting immunity to tetanus. Copyright © 2014 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Gaayeb, Lobna
France, Lille
Université de Lille
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé
Sarr, Jean B.
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé
Cames, Cécile
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Pinçon, Claire
France, Lille
Université de Lille
Hanon, Jean Baptiste
France, Lille
Université de Lille
Ndiath, Mamadou Ousmane
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Seck, Modou
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé
Herbert, Fabien
France, Lille
Université de Lille
Sagna, André Barembaye
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé
Schacht, Anne Marie
France, Lille
Université de Lille
Remoué, Franck J.
Benin, Cotonou
Centre de Recherche Entomologique de Cotonou
Riveau, Gilles J.
France, Lille
Université de Lille
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé
Hermann, Emmanuel
France, Lille
Université de Lille
Statistics
Citations: 17
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.4269/ajtmh.12-0657
ISSN:
00029637
Research Areas
Food Security
Health System And Policy
Maternal And Child Health
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Senegal