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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Plasma γ-glutamyltransferase, cysteinyl-glycine, and oxidized low-density lipoprotein: A pathway associated with myocardial infarction risk?
Arteriosclerosis, Thrombosis, and Vascular Biology, Volume 30, No. 10, Year 2010
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Description
Objective-: To investigate the interrelation between plasma γ-glutamyltransferase (GGT) activity, cysteinyl-glycine (Cys-Gly) (ie, a thiol originating from GGT-mediated cleavage of glutathione), and oxidized low-density lipoprotein (oxLDL) with regard to myocardial infarction (MI) risk in a prospective study. Methods and results-: Incident cases of MI were identified among European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam participants without prior MI during 6.0 years of follow-up. Baseline levels of Cys-Gly and oxLDL and GGT activity in plasma were measured in a case-cohort study comprising 837 subjects without incident MI and 116 subjects with incident MI. The relation of GGT, Cys-Gly and oxLDL to MI risk was assessed using Cox proportional hazards regression analysis. After adjustment for established risk factors, hazard ratios associated with a 1-SD unit increase in the log-transformed biomarker were 1.63 (95% CI, 1.30 to 2.05) for GGT, 1.36 (95% CI, 1.07 to 1.72) for Cys-Gly, and 1.37 (95% CI, 1.00 to 1.86) for oxLDL. Cys-Gly and oxLDL accounted for 2.3% of the relation between GGT and MI risk. Conclusion-: The positive association between GGT activity and MI risk appears to be independent of circulating Cys-Gly and oxLDL levels. With Cys-Gly, we found a potential new predictor of MI risk whose impact needs to be further elucidated. © 2010 American Heart Association, Inc.
Authors & Co-Authors
Drogan, Dagmar
Germany, Nuthetal
German Institute of Human Nutrition
Weikert, Cornelia
Germany, Nuthetal
German Institute of Human Nutrition
Dierkes, Jutta
Germany, Magdeburg
Otto-von-guericke-universität Magdeburg
Norway, Bergen
Universitetet I Bergen
Klipstein-Grobusch, Kerstin
Germany, Nuthetal
German Institute of Human Nutrition
Buijsse, Brian
Germany, Nuthetal
German Institute of Human Nutrition
Möhlig, Matthias
South Africa, Johannesburg
Wits School of Public Health
Germany, Nuthetal
German Institute of Human Nutrition
Pfeiffer, Andreas F.H.
South Africa, Johannesburg
Wits School of Public Health
Germany, Nuthetal
German Institute of Human Nutrition
Pischon, Tobias
Germany, Nuthetal
German Institute of Human Nutrition
Spranger, Joachim Andreas
South Africa, Johannesburg
Wits School of Public Health
Germany, Nuthetal
German Institute of Human Nutrition
Boeing, Heiner
Germany, Nuthetal
German Institute of Human Nutrition
Germany, Berlin
Charité – Universitätsmedizin Berlin
Statistics
Citations: 18
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1161/ATVBAHA.110.209346
ISSN:
10795642
Research Areas
Cancer
Environmental
Food Security
Study Design
Cohort Study
Study Approach
Quantitative