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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Nitrosatable amines and nitrosamide formation in natural stimulants: Cola acuminata, C. nitida and Garcinia cola
Food and Chemical Toxicology, Volume 33, No. 8, Year 1995
Notification
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Description
Three varieties of kola nut, Cola acuminata, C. nitida and Garcinia cola, of Nigerian origin, were analysed for their content of primary and secondary amines, and assessed for their relative methylating potential due to nitrosamide formation. Primary and secondary amines were determined as benzene sulfonamides by gas chromatography/thermal energy analysis (GC/TEA). Dimethylamine, methylamine, ethylamine and isopentylamine were detected in all kola nut varieties, while pyrrolidine, piperidine and isobutylamine were detected in one or more varieties. Estimated average total daily intake of aliphatic amines by a typical kola nut chewer varied from 260 to 1040 μg/day for secondary amines and from 2430 to 9710μg/day for primary amines. Methylating activity of the nitrosated kola nuts, expressed as N-nitroso-N-methylurea equivalents, was also determined by GC/TEA. Methylating activity was significantly higher in kola nuts (170-490 μg/kg) than has ever been reported for a fresh plant product. These data suggest that the possible role of kola nut chewing in human cancer aetiology should be explored in countries where kola nuts are widely consumed as stimulants. © 1995.
Authors & Co-Authors
Atawodi, Sunday Ene Ojo
Germany, Heidelberg
German Cancer Research Center
Pfundstein, Beate
Germany, Heidelberg
German Cancer Research Center
Preußmann, Rudolf A.
Germany, Heidelberg
German Cancer Research Center
Spiegelhalder, Berthold
Germany, Heidelberg
German Cancer Research Center
Statistics
Citations: 49
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1016/0278-6915(95)00035-Z
ISSN:
02786915
Research Areas
Cancer