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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Effect of active immunization against inhibin on hormonal concentrations and semen characteristics in Shiba bucks
Theriogenology, Volume 65, No. 4, Year 2006
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Description
Active immunization against inhibin increased ovulation rate in females; in males, the effects of active immunization against inhibin on hormonal concentrations and sperm production need more investigation. To test the hypothesis that active immunization against inhibin increases FSH secretion and sperm output, the present study was undertaken to determine the effects of active immunization against inhibin on hormonal profile and sperm production in Shiba bucks. The bucks were actively immunized against inhibin α-subunit (immunized group, n = 6) or Freund adjuvant (control group, n = 5) four times, at 5-weeks intervals. Blood samples were collected twice-weekly and two successive ejaculates of semen were collected (with an artificial vagina) once-weekly. Plasma concentrations of FSH, LH and testosterone were measured by radioimmunoassay (RIA) and sperm motility characteristics were measured by computer-assisted sperm analysis (CASA). All inhibin-immunized bucks produced antibodies against inhibin. Relative to control bucks, in immunized bucks there were significant increases in plasma FSH concentrations and in sperm concentrations from 5 to 9 weeks and from 8 to 11 weeks, respectively, after primary immunization. However, plasma concentrations of LH and testosterone, semen volume, percentage of motile spermatozoa and motility parameters (straight-line velocity, curvilinear velocity and linearity index) were similar in both groups. In conclusion, active immunization against inhibin α-subunit increased FSH secretions and enhanced sperm production in bucks, whereas LH and testosterone concentrations, semen volume and sperm motility parameters were unaffected. Active immunization against inhibin could be used to improve fertility in Shiba bucks. © 2005 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Medan, Mohamed Sabry
Japan, Fuchu
Tokyo University of Agriculture and Technology
Egypt, Ismailia
Faculty of Veterinary Medicine
Watanabe, Gen
Egypt, Ismailia
Faculty of Veterinary Medicine
Japan, Gifu
Gifu University
Nagura, Yoshio
Japan, Nishishirakawa District
National Livestock Breeding Center, Incorporated Administrative Agency
Fujita, Masaru
Japan, Nishishirakawa District
National Livestock Breeding Center, Incorporated Administrative Agency
Taya, Kazuyoshi
Egypt, Ismailia
Faculty of Veterinary Medicine
Japan, Gifu
Gifu University
Japan, Fuchu
Tokyo University of Agriculture and Technology
Statistics
Citations: 10
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1016/j.theriogenology.2005.06.007
ISSN:
0093691X
Research Areas
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Participants Gender
Female