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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Incidence and risk factors for community-acquired hepatitis C infection from birth to 5 years of age in rural Egyptian children
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, No. 5, Year 2010
Notification
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Description
A prospective study in three Egyptian villages (A, B and C) having a high prevalence of hepatitis C virus (HCV) infection examined incidence of community-acquired HCV infection in children; 2852 uninfected infants were prospectively followed from birth for up to 5.5 years. Fifteen seroconverted for either HCV antibodies and/or HCV-RNA (incidence of 0.53%). Ten had both anti-HCV and HCV-RNA; four had only anti-HCV; and one had HCV-RNA in the absence of antibody. The incidence rate at all ages was 2.7/1000 person-years (PY). It was 3.8/1000 PY during infancy and 2.0/1000 PY for the 1-5-years age group. Hospitalization and low birth weight increased the risk of infection; while living in village B, the family having a higher socioeconomic status, and advanced maternal education were protective. Six of eight HCV-infected infants reported iatrogenic exposures (e.g. hospitalization, therapeutic injections, ear piercing) prior to infection whereas only 2/7 children older than 1 year reported these exposures. Having an HCV-positive mother was the only other reported risk in two of these older children. The virus cleared in six (40%) children by the end of follow-up. Health education targeting iatrogenic exposures and focusing on risk factors could reduce HCV infection in children in high-risk populations. © 2010 Royal Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Saleh, Doa'a A.
Egypt, Cairo
Faculty of Medicine
Shebl, Fatma Mohamed
United States, Baltimore
University of Maryland School of Medicine
Egypt, Shibin el Kom
Menoufia University
El-Kamary, Samer S.
United States, Baltimore
University of Maryland School of Medicine
Magder, Laurence S.
United States, Baltimore
University of Maryland School of Medicine
Allam, Alif Abdel Hakim
Egypt, Shibin el Kom
Menoufia University
Abdel-Hamid, Mohamed A.
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Egypt, Minya
Minia University
NNH Mikhail, Nabiel N.H.
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Egypt, Asyut
Assiut University
Hashem, Mohamed S.
United States, Baltimore
University of Maryland School of Medicine
Sharaf, Soraya A.
Egypt, Shibin el Kom
Menoufia University
Stoszek, Sonia Karolina
United States, Baltimore
University of Maryland School of Medicine
Strickland, George Thomas
United States, Baltimore
University of Maryland School of Medicine
Statistics
Citations: 37
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1016/j.trstmh.2010.01.009
ISSN:
00359203
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study