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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Estimates of possible severe bacterial infection in neonates in sub-Saharan Africa, south Asia, and Latin America for 2012: A systematic review and meta-analysis
The Lancet Infectious Diseases, Volume 14, No. 8, Year 2014
Notification
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Description
Background: Bacterial infections are a leading cause of the 2·9 million annual neonatal deaths. Treatment is usually based on clinical diagnosis of possible severe bacterial infection (pSBI). To guide programme planning, we have undertaken the first estimates of neonatal pSBI, by sex and by region, for sub-Saharan Africa, south Asia, and Latin America. Methods: We included data for pSBI incidence in neonates of 32 weeks' gestation or more (or birthweight ≥1500 g) with livebirth denominator data, undertaking a systematic review and forming an investigator group to obtain unpublished data. We calculated pooled risk estimates for neonatal pSBI and case fatality risk, by sex and by region. We then applied these risk estimates to estimates of livebirths in sub-Saharan Africa, south Asia, and Latin America to estimate cases and associated deaths in 2012. Findings: We included data from 22 studies, for 259 944 neonates and 20 196 pSBI cases, with most of the data (18 of the 22 studies) coming from the investigator group. The pooled estimate of pSBI incidence risk was 7·6% (95% CI 6·1-9·2%) and the case-fatality risk associated with pSBI was 9·8% (7·4-12·2). We estimated that in 2012 there were 6·9 million cases (uncertainty range 5·5 million-8·3 million) of pSBI in neonates needing treatment: 3·5 million (2·8 million-4·2 million) in south Asia, 2·6 million (2·1 million-3·1 million) in sub-Saharan Africa, and 0·8 million (0·7 million-1·0 million) in Latin America. The risk of pSBI was greater in boys (risk ratio 1·12, 95% CI 1·06-1·18) than girls. We estimated that there were 0·68 million (0·46 million-0·92 million) neonatal deaths associated with pSBI in 2012. Interpretation: The need-to-treat population for pSBI in these three regions is high, with ten cases of pSBI diagnosed for each associated neonatal death. Deaths and disability can be reduced through improved prevention, detection, and case management. Funding: The Wellcome Trust and the Bill & Melinda Gates Foundation through grants to Child Health Epidemiology Reference Group (CHERG) and Save the Children's Saving Newborn Lives programme. © 2014 Seale et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4123782/bin/mmc1.pdf
Authors & Co-Authors
Seale, Anna C.
Unknown Affiliation
Blencowe, Hannah K.
Unknown Affiliation
Manu, Alexander Ansah
Unknown Affiliation
Nair, Harish
Unknown Affiliation
Bahl, Rajiv
Unknown Affiliation
Qazi, Shamim Ahmad
Unknown Affiliation
Zaidi, Anita Kaniz Mehdi
Unknown Affiliation
Berkley, James A.
Unknown Affiliation
Cousens, Simon Nicholas
Unknown Affiliation
Lawn, Joy E.
Unknown Affiliation
Agustian, Dwi
Unknown Affiliation
Althabe, Fernando A.
Unknown Affiliation
Azziz-Baumgartner, Eduardo
Unknown Affiliation
Baqui, Abdullah Hel
Unknown Affiliation
Bausch, Daniel G.
Unknown Affiliation
Belizán, J.
Unknown Affiliation
Qar Bhutta, Zulfi
Unknown Affiliation
Black, Robert E.
Unknown Affiliation
Broor, Shobha L.
Unknown Affiliation
Bruce, Nigel G.
Unknown Affiliation
Buekens, Pierre M.
Unknown Affiliation
Campbell, Harry
Unknown Affiliation
Carlo, Waldemar A.
Unknown Affiliation
Chomba, Elwyn Nachanya
Unknown Affiliation
Costello, Anthony Ml De L.
Unknown Affiliation
Derman, Richard J.
Unknown Affiliation
Dherani, Mukesh K.
Unknown Affiliation
Arifeen, Shams E.
Unknown Affiliation
Engmann, Cyril Mark
Unknown Affiliation
Esamai, Fabian O.
Unknown Affiliation
Ganatra, Hammad Ashraf
Unknown Affiliation
Garcés, Ana Lucía
Unknown Affiliation
Gessner, Bradford D.
Unknown Affiliation
Gill, Christopher John
Unknown Affiliation
Goldenberg, Robert L.
Unknown Affiliation
Goudar, Shivaprasad S.
Unknown Affiliation
Hambidge, K. Michael
Unknown Affiliation
Hamer, Davidson Howes
Unknown Affiliation
Hansen, Nellie I.
Unknown Affiliation
Hibberd, Patricia L.
Unknown Affiliation
Khanal, Sudhir
Unknown Affiliation
Kirkwood, Betty R.
Unknown Affiliation
Kosgei, Patrick
Unknown Affiliation
Koso-Thomas, Marion W.
Unknown Affiliation
Liechty, Edward A.
Unknown Affiliation
McClure, Elizabeth M.
Unknown Affiliation
Mitra, Dipak K.
Unknown Affiliation
Mturi, Neema
Unknown Affiliation
Mullany, Luke C.
Unknown Affiliation
Newton, Charles R.J.C.
Unknown Affiliation
Nosten, François Henry
Unknown Affiliation
Parveen, Shama
Unknown Affiliation
Patel, Archana Behram
Unknown Affiliation
Romero, Candice
Unknown Affiliation
Saville, Naomi M.
Unknown Affiliation
Semrau, Katherine E.A.
Unknown Affiliation
Simoẽs, Eric A.F.
Unknown Affiliation
Soofi, Sajid Bashir
Unknown Affiliation
Stoll, Barbara J.
Unknown Affiliation
Sunder, Shiyam
Unknown Affiliation
Syed, Sana
Unknown Affiliation
Tielsch, James M.
Unknown Affiliation
Tinoco, Yeny O.
Unknown Affiliation
Turner, Claudia L.
Unknown Affiliation
Vergnano, Stefania
Unknown Affiliation
Statistics
Citations: 256
Authors: 65
Affiliations: 9
Identifiers
Doi:
10.1016/S1473-3099(14)70804-7
ISSN:
14733099
e-ISSN:
14744457
Research Areas
Disability
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Systematic review
Participants Gender
Male
Female