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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
NTCP S267F variant associates with decreased susceptibility to HBV and HDV infection and decelerated progression of related liver diseases
International Journal of Infectious Diseases, Volume 80, Year 2019
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Description
Objectives: To determine potential associations of the rs2296651 variant (c.800C > T, S267F) of NTCP with HBV and HBV plus concomitant HDV infection as well as with the progression of related liver diseases. Methods: The S267F variant was genotyped by DNA sequencing in 620 HBV-infected patients and 214 healthy controls (HCs). Among the patients, 450 individuals were tested for HDV by a nested PCR assay. Logistic regression was applied to examine the association. Results: The S267F variant was found more frequently among HCs (16%) compared to HBV-infected (6%) and HBV-HDV co-infected patients (3%) (HBV patients vs HC: OR = 0.32, P = 0.00002 and HDV patients vs. HC: OR = 0.17, P = 0.018). The frequency of S267F variant was inversely correlated with CHB, LC or HCC patients compared with HCs (OR = 0.31, P = 0.001; OR = 0.32, P = 0.013; OR = 0.34, P = 0.002, respectively). S267F variant was also associated with decreased risk of the development of advanced liver cirrhosis (LC) and hepatocellular carcinoma (HCC) (Child B and C vs. Child A, OR = 0.26, adjusted P = 0.016; BCLC B,C,D vs. BCLC A, OR = 0.038, P = 0.045, respectively). In addition, patients with the genotype CT had lower levels of AST, ALT, total and direct bilirubin as well as higher platelet counts, indicating an association with a more favorable clinical outcome. Conclusion: The NTCP S267F variant of the SLC10A1 gene exhibits protective effects against HBV and HDV infection and is associated with a reduced risk of developing to advanced stages of LC and HCC. © 2019 The Author(s)
Authors & Co-Authors
Binh, Mai Thanh
Germany, Tubingen
Eberhard Karls Universität Tübingen
Viet Nam, Hanoi
Vietnamese-german Center for Medical Research
Viet Nam, Hanoi
108 Military Central Hospital
Hoan, Nghiem Xuan
Germany, Tubingen
Eberhard Karls Universität Tübingen
Viet Nam, Hanoi
Vietnamese-german Center for Medical Research
Viet Nam, Hanoi
108 Military Central Hospital
van Tong, Hoang
Germany, Tubingen
Eberhard Karls Universität Tübingen
Viet Nam, Hanoi
Vietnamese-german Center for Medical Research
Viet Nam, Hanoi
Vietnam Military Medical University
Sy, Bui Tien
Viet Nam, Hanoi
Vietnamese-german Center for Medical Research
Viet Nam, Hanoi
108 Military Central Hospital
Trung, Ngo Tat
Viet Nam, Hanoi
Vietnamese-german Center for Medical Research
Viet Nam, Hanoi
108 Military Central Hospital
Bock, C. Thomas
Germany, Tubingen
Eberhard Karls Universität Tübingen
Germany, Berlin
Robert Koch Institute
Toan, Nguyen Linh
Viet Nam, Hanoi
Vietnamese-german Center for Medical Research
Viet Nam, Hanoi
Vietnam Military Medical University
Song, Lehuu
Viet Nam, Hanoi
Vietnamese-german Center for Medical Research
Viet Nam, Hanoi
108 Military Central Hospital
Bang, Maihong
Viet Nam, Hanoi
108 Military Central Hospital
Meyer, Christian G.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Viet Nam, Hanoi
Vietnamese-german Center for Medical Research
Viet Nam, Da Nang
Duy Tan University
Kremsner, Peter G.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Velavan, Thirumalaisamy P.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Viet Nam, Hanoi
Vietnamese-german Center for Medical Research
Viet Nam, Da Nang
Duy Tan University
Statistics
Citations: 21
Authors: 12
Affiliations: 6
Identifiers
Doi:
10.1016/j.ijid.2019.01.038
ISSN:
12019712
Research Areas
Cancer
Genetics And Genomics
Maternal And Child Health