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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Lactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12
Malaria Journal, Volume 5, Article 101, Year 2006
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Description
Background: Hyperlactataemia is often associated with a poor outcome in severe malaria in African children. To unravel the complex pathophysiology of this condition the relationship between plasma lactate levels, parasite density, pro- and anti-inflammatory cytokines, and haemozoin-containing leucocytes was studied in children with severe falciparum malarial anaemia. Methods: Twenty-six children with a primary diagnosis of severe malarial anaemia with any asexual Plasmodium falciparum parasite density and Hb < 5 g/dL were studied and the association of plasma lactate levels and haemozoin-containing leucocytes, parasite density, pro- and anti-inflammatory cytokines was measured. The same associations were measured in non-severe malaria controls (N = 60). Results: Parasite density was associated with lactate levels on admission (r = 0.56, P < 0.005). Moreover, haemozoin-containing neutrophils and IL-12 were strongly associated with plasma lactate levels, independently of parasite density (r = 0.60, P = 0.003 and r = -0.46, P = 0.02, respectively). These associations were not found in controls with uncomplicated malarial anaemia. Conclusion: These data suggest that blood stage parasites, haemozoin and low levels of IL-12 may be associated with the development of hyperlactataemia in severe malarial anaemia. © 2006 Casals-Pascual et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Casals-Pascual, Climent
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Kai, Oscar K.
Kenya, Kilifi
Kemri Centre for Geographic Medical Research
Lowe, Brett S.
United Kingdom, Oxford
John Radcliffe Hospital
Kenya, Kilifi
Kemri Centre for Geographic Medical Research
English, Michael C.
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Kenya, Kilifi
Kemri Centre for Geographic Medical Research
Williams, Thomas Neil
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Kenya, Kilifi
Kemri Centre for Geographic Medical Research
Maitland, Kathryn M.
Kenya, Kilifi
Kemri Centre for Geographic Medical Research
United Kingdom, London
Imperial College London
Newton, Charles R.J.C.
Kenya, Kilifi
Kemri Centre for Geographic Medical Research
United Kingdom, London
Institute for Child Health
Peshu, Norbert M.
Kenya, Kilifi
Kemri Centre for Geographic Medical Research
Roberts, David J.
United Kingdom, Oxford
University of Oxford Medical Sciences Division
United Kingdom, Oxford
John Radcliffe Hospital
Statistics
Citations: 17
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1186/1475-2875-5-101
ISSN:
14752875
e-ISSN:
14752875
Research Areas
Infectious Diseases
Maternal And Child Health