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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Return of chloroquine-susceptible falciparum malaria in malawi was a reexpansion of diverse susceptible parasites
Journal of Infectious Diseases, Volume 202, No. 5, Year 2010
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Description
The spread of drug-resistant Plasmodium falciparum malaria has been a major impediment to malaria control and threatens prospects for elimination. We recently demonstrated the return of chloroquine-susceptible malaria in Malawi after chloroquine use was abandoned. In this study, we trace the origins of chloroquineresistant and chloroquine-susceptible parasites in Malawi by sequencing the P. falciparum chloroquine resistance transporter gene (pfcrt) and by genotyping microsatellites flanking this gene in isolates from infections that occurred in Malawi from 1992 through 2005. Malaria parasites from 2005 harbored the expected wildtype pfcrt haplotype associated with chloroquine susceptibility and have maintained high levels of diversity without linkage disequilibrium, which suggests that the return of chloroquine susceptibility is not the result of a back mutation in a formerly resistant parasite or a new selective sweep. Chloroquine-susceptible parasites that predominate in Malawi likely represent a reexpansion of the susceptible parasites that survived in the population despite widespread drug pressure in the region. © 2010 by the Infectious Diseases Society of America.
Authors & Co-Authors
Laufer, Miriam K.
United States, Baltimore
University of Maryland School of Medicine
Malawi, Zomba
University of Malawi
Takala-Harrison, Shannon L.
United States, Baltimore
University of Maryland School of Medicine
Dzinjalamala, Fraction K.
Malawi, Zomba
University of Malawi
Stine, Oscar Colin
Unknown Affiliation
Taylor, Terrie Ellen
United States, East Lansing
Msu College of Osteopathic Medicine
Malawi, Zomba
University of Malawi
Plowe, Christopher Vv
United States, Baltimore
University of Maryland School of Medicine
Statistics
Citations: 148
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1086/655659
ISSN:
00221899
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Malawi