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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera
Molecules, Volume 12, No. 8, Year 2007
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Description
In a preliminary antiprotozoal screening of several Clusiaceae species, the methanolic extracts of Allanblackia monticola and Symphonia globulifera showed high in vitro leishmanicidal activity. Further bioguided phytochemical investigation led to the isolation of four benzophenones: guttiferone A (1), garcinol (2), cambogin (3) and guttiferone F (4), along with three xanthones: allanxanthone A (5), xanthone V1 (6) and globulixanthone C (7) as active constituents. Compounds 1 and 6 were isolated from S. globulifera leaves, while compounds 2-5 were obtained from A. monticola fruits. Guttiferone A (1) and F (4) showed particulary strong leishmanicidal activity in vitro, with IC50 values (0.2 μM and 0.16 μM, respectively) comparable to that of the reference compound, miltefosine (0.46 μM). Although the leishmanicidal activity is promising, the cytotoxicity profile of these compounds prevent at this state further in vivo biological evaluation. In addition, all the isolated compounds were tested in vitro for their anticholinesterase properties. The four benzophenones showed potent anticholinesterase properties towards acetylcholinesterase (AChE) and butylcholinesterase (AChE). For AChE, the IC50 value (0.66 μM) of garcinol (2) was almost equal to that of the reference compound galanthamine (0.50 μM). Furthermore, guttiferone A (1) and guttiferone F (4) (IC 50 = 2.77 and 3.50 μM, respectively) were more active than galanthamine (IC50 = 8.5) against BChE. © 2007 by MDPI.
Authors & Co-Authors
Lenta, Bruno Ndjakou
Cameroon, Yaounde
Université de Yaoundé I
Germany, Bielefeld
Universität Bielefeld
Vonthron-Sénécheau, Cathérine
France, Caen
Université de Caen Normandie
Weniger, Bernard
France, Strasbourg
Université de Strasbourg
Devkota, Krishna Prasad
Germany, Bielefeld
Universität Bielefeld
Ngoupayo, Joseph
Cameroon, Yaounde
Université de Yaoundé I
Kaiser, Marcel
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Naz, Qamar
Pakistan, Karachi
University of Karachi
Choudhary, Mohammed Iqbal
Pakistan, Karachi
University of Karachi
Tsamo, Etienne
Cameroon, Yaounde
Université de Yaoundé I
Sewald, Norbert
Germany, Bielefeld
Universität Bielefeld
Statistics
Citations: 85
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.3390/12081548
e-ISSN:
14203049